PD-L1 expression downregulation by RNF43 in gastric carcinoma enhances antitumour activity of T cells

被引：0
|
作者：
Yang, Jing [1 ]
Wei, Meng [2 ,3 ]
Liu, Xin [4 ]
Shao, Xiao [5 ]
Yan, Jingshuang [1 ]
Liu, Jialong [6 ]
Wen, Jing [7 ]
Zhang, Xueting [1 ]
Dong, Ruihua [8 ]
Min, Min [1 ,9 ]
机构：
[1] Chinese Peoples Liberat Army Gen Hosp, Dept Gastroenterol, Med Ctr 1, Beijing, Peoples R China
[2] Guangxi Med Univ, Dept Hepatobiliary Surg, Affiliated Tumor Hosp, Nanning, Peoples R China
[3] Guangxi Med Univ, Key Lab High Incidence Tumor Prevent & Treatment, Minist Educ, Nanning, Peoples R China
[4] Chinese Peoples Liberat Army Gen Hosp, Dept Lab Med, Med Ctr 8, Beijing, Peoples R China
[5] Chinese Peoples Liberat Army Gen Hosp, Dept Pharmacol, Med Ctr 5, Beijing, Peoples R China
[6] Acad Mil Med Sci AMMS, Beijing Inst Biotechnol, Beijing, Peoples R China
[7] Chinese PLA 984 Hosp, Dept Gastroenterol, Beijing, Peoples R China
[8] Capital Med Univ, Beijing Friendship Hosp, Dept Res Ward, Beijing, Peoples R China
[9] Chinese Peoples Liberat Army Gen Hosp, Gastroenterol, Med Ctr 1, Beijing 100853, Peoples R China
来源：
SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 2023年 / 97卷 / 06期
关键词：
cellular immunotherapy; gastric cancer; PD-L1; RNF43; ubiquitination; CANCER; CONTRIBUTES; CHINA;
D O I：
10.1111/sji.13268
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Ring finger protein 43 (RNF43), a transmembrane E3 ubiquitin ligase, has been indicated to be a potential biomarker for gastric cancer treatment, as this protein increases tumour cell apoptosis and suppresses cellular proliferation. The role of RNF43 in cellular immunotherapy remains unclear. Herein, we aimed to explore the expression level of RNF43 in gastric cancer cell lines and its role in cellular immunotherapy. The expression level of RNF43 and PD-L1 and their correlation in gastric cancer cell lines were analysed. The expression of PD-L1 was negatively correlated with that of RNF43 in gastric cancer cell lines. RNF43 interacted with PD-L1 to augment both K48- and K63-linked ubiquitination of PD-L1 in gastric cancer cell lines. In addition, RNF43 expression in gastric cancer cell lines could enhance the antitumour activity of T cells. In conclusion, this study reveals that RNF43 can inhibit PD-L1 expression to enhance the antitumour activity of cellular immunotherapy.
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页数：10
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