Endovascular Therapy for Basilar Artery Occlusion

被引:41
作者
Alemseged, Fana [1 ]
Nguyen, Thanh N. [2 ]
Alverne, Francisco Mont' [3 ]
Liu, Xinfeng [4 ,5 ,6 ]
Schonewille, Wouter J. [7 ]
Nogueira, Raul G. [8 ,9 ]
机构
[1] Univ Melbourne, Royal Melbourne Hosp, Dept Med & Neurol, Parkville, Vic, Australia
[2] Boston Univ, Boston Med Ctr, Dept Neurol & Radiol, Chobanian & Avedisian Sch Med, Boston, MA USA
[3] Hosp Geral Fortaleza, Dept Neurol & Intervent Neuroradiol, Fortaleza, Ceara, Brazil
[4] Univ Sci & Technol China, Affiliated Hosp USTC 1, Stroke Ctr, Hefei, Peoples R China
[5] Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Neurol, Hefei, Peoples R China
[6] Nanjing Univ, Affiliated Jinling Hosp, Dept Neurol, Med Sch, Nanjing, Peoples R China
[7] St Antonius Hosp, Dept Neurol, Nieuwegein, Netherlands
[8] Univ Pittsburgh, UPMC Stroke Inst, Dept Neurol, Pittsburgh, PA USA
[9] Univ Pittsburgh, UPMC Stroke Inst, Dept Neurosurg, Pittsburgh, PA USA
关键词
basilar artery ischemia; mortality; reperfusion; stroke; thrombectomy; ACUTE ISCHEMIC-STROKE; POSTERIOR CIRCULATION; INTRAVENOUS THROMBOLYSIS; FAVORABLE OUTCOMES; VESSEL OCCLUSION; THROMBECTOMY; RECANALIZATION; TRIAL; TIME; HYPOATTENUATION;
D O I
10.1161/STROKEAHA.122.040807
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Basilar artery occlusion is one of the most devastating neurological conditions with high risks of disability and mortality. Despite the overwhelming benefit of endovascular therapy (EVT) in the anterior circulation and observational data supporting the efficacy of EVT in the posterior circulation, evidence from randomized controlled trials in basilar artery occlusion had been lacking until recently. The BEST (Basilar Artery Occlusion Endovascular Intervention Versus Standard Medical Treatment) and BASICS (Basilar Artery International Cooperation Study) randomized trials showed a nonsignificant direction of benefit but failed to demonstrate the superiority of EVT over standard medical therapy in basilar artery occlusion. However, these trials paved the way for 2 subsequent positive trials by highlighting the importance of consecutive recruitment, fast enrollment and avoidance or minimization of cross-over. The recently completed ATTENTION (Endovascular Treatment for Acute Basilar Artery Occlusion) and BAOCHE (Basilar Artery Occlusion Chinese Endovascular Trial) trials showed that EVT is beneficial for basilar artery occlusion within 24 hours of onset, with a treatment effect similar to what has been shown in anterior circulation large vessel occlusion ischemic stroke. In this topical review, we examine and contextualize the current evidence on EVT for basilar artery occlusion.
引用
收藏
页码:1127 / 1137
页数:11
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