Three-in-one self-assembled metallo-nanophotosensitizers for photodynamic/chemodynamic/chemo multimodal synergistic cancer therapy

被引：4

作者：

Chao, Shuang ^{[1
,2
]}

Shen, Ziyan ^{[2
]}

Ren, Jiaming ^{[2
]}

Zhang, Zhilin ^{[2
]}

Chen, Xiaolin ^{[2
]}

Pei, Yuxin ^{[2
]}

Pei, Zhichao ^{[1
,2
]}

机构：

[1] Northwest A&F Univ, Coll Plant Protect, Yangling 712100, Shaanxi, Peoples R China

[2] Northwest A&F Univ, Coll Chem & Pharm, Shaanxi Key Lab Nat Prod & Chem Biol, Yangling 712100, Shaanxi, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 30期

基金：

中国国家自然科学基金;

关键词：

PHOTODYNAMIC THERAPY; VESICLES; PHOTOSENSITIZERS; DESIGN;

D O I：

10.1039/d3cc00469d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A three-in-one self-assembled metallo-nanophotosensitizer system (NLCD) was constructed by cooperative coordination of amphiphilic l-arginine-modified photosensitizer NBS-l-Arg and DOX in the presence of Cu(2+)via the synergy of coordination, hydrophobic, and pi-pi stacking interactions. The resulting NLCD NPs possessed uniform size, well-defined nanosphere structure, and GSH-responsive ability. In vitro studies exhibited that NLCD NPs integrating photodynamic/chemodynamic/chemo multimodal therapy achieved an enhanced therapeutic effect.

引用

页码：4479 / 4482

页数：4

共 42 条

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