Pregnancy Outcomes of Freeze-All versus Fresh Embryo Transfer in Women with Adenomyosis: A Retrospective Study

被引：1

作者：

Zhang, Qiaoli ^{[1
]}

Chen, Qiaoyuan ^{[1
]}

Li, Tianhe ^{[2
]}

Jia, Zhaoxia ^{[3
]}

Bu, Xiaomeng ^{[1
]}

Liu, Yanjun ^{[1
]}

Wang, Shuyu ^{[1
]}

Liu, Ying ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Obstet & Gynecol Hosp, Beijing Maternal & Child Hlth Care Hosp, Dept Human Reprod Med, 251 Yaojiayuan Rd, Beijing 100026, Peoples R China

[2] Capital Med Univ, Beijing Obstet & Gynecol Hosp, Beijing Maternal & Child Hlth Care Hosp, Cent Lab, 251 Yaojiayuan Rd, Beijing 100026, Peoples R China

[3] Capital Med Univ, Beijing Obstet & Gynecol Hosp, Beijing Maternal & Child Hlth Care Hosp, Dept Informat & Stat, 251 Yaojiayuan Rd, Beijing 100026, Peoples R China

来源：

JOURNAL OF CLINICAL MEDICINE | 2023年 / 12卷 / 05期

关键词：

adenomyosis; infertility; in vitro fertilization; freeze-all; fresh embryo transfer; pregnancy outcome; IN-VITRO FERTILIZATION; UTERINE VOLUME; RISK; CRYOPRESERVATION; IMPLANTATION; MISCARRIAGE; PREVALENCE; DIAGNOSIS; CYCLES; IMPACT;

D O I：

10.3390/jcm12051740

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Adenomyosis has been associated with adverse fertility and pregnancy outcomes, and its impact on the outcomes of in vitro fertilization (IVF) has received much attention. It is controversial whether the freeze-all strategy is better than fresh embryo transfer (ET) in women with adenomyosis. Women with adenomyosis were enrolled in this retrospective study from January 2018 to December 2021 and were divided into two groups: freeze-all (n = 98) and fresh ET (n = 91). Data analysis showed that freeze-all ET was associated with a lower rate of premature rupture of membranes (PROM) compared with fresh ET (1.0% vs. 6.6%, p = 0.042; adjusted OR 0.17 (0.01-2.50), p = 0.194). Freeze-all ET also had a lower risk of low birth weight compared with fresh ET (1.1% vs. 7.0%, p = 0.049; adjusted OR 0.54 (0.04-7.47), p = 0.642). There was a nonsignificant trend toward a lower miscarriage rate in freeze-all ET (8.9% vs. 11.6%; p = 0.549). The live birth rate was comparable in the two groups (19.1% vs. 27.1%; p = 0.212). The freeze-all ET strategy does not improve pregnancy outcomes for all patients with adenomyosis and may be more appropriate for certain patients. Further large-scale prospective studies are needed to confirm this result.

引用

页数：11

共 45 条

[21] Adenomyosis does not affect implantation, but is associated with miscarriage in patients undergoing oocyte donation [J].