Novel roles of RNA-binding proteins in drug resistance of breast cancer: from molecular biology to targeting therapeutics

被引：15

作者：

Cen, Yinghuan ^{[1
,2
]}

Chen, Letian ^{[1
,2
]}

Liu, Zihao ^{[3
]}

Lin, Qun ^{[1
,2
]}

Fang, Xiaolin ^{[1
,2
]}

Yao, Herui ^{[1
,2
]}

Gong, Chang ^{[1
,2
]}

机构：

[1] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangdong Prov Key Lab Malignant Tumor Epigenet &, Guangzhou 510120, Peoples R China

[2] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Breast Tumor Ctr, Guangzhou 510120, Peoples R China

[3] Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1,Dept Breast & Thyroid Surg,Clin, Shenzhen 518020, Peoples R China

来源：

CELL DEATH DISCOVERY | 2023年 / 9卷 / 01期

关键词：

ENDOCRINE RESISTANCE; MESSENGER-RNA; PROMOTES CHEMORESISTANCE; TRANSLATIONAL CONTROL; STRANDED-RNA; CELL-GROWTH; IN-VIVO; COMPLEX; FAMILY; GENE;

D O I：

10.1038/s41420-023-01352-x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Therapy resistance remains a huge challenge for current breast cancer treatments. Exploring molecular mechanisms of therapy resistance might provide therapeutic targets for patients with advanced breast cancer and improve their prognosis. RNA-binding proteins (RBPs) play an important role in regulating therapy resistance. Here we summarize the functions of RBPs, highlight their tremendously important roles in regulating therapy sensitivity and resistance and we also reveal current therapeutic approaches reversing abnormal functions of RBPs in breast cancer.

引用

页数：10

共 117 条

[1] Posttranscriptional regulation of cancer traits by HuR [J].