In 2020 and 2021, the emergence of a new communicable disease (Covid-19) surpassed the main causes of death in force until then, marking a milestone in the epidemiological transition. The general objective of this work is to describe the distribution of fatality in indigenous and non -indigenous people in Mexico due to Covid-19 in the period 2020 to 2022. Based on accumulated data from the Epidemiological Surveillance System for Respiratory Diseases of Mexico, with cutoff on October 4, 2022, the greater lethality of indigenous language speakers is confirmed, compared to the rest of the population. The entities and regions where the effects of the pandemic were (un)balanced are highlighted, which is why it is suggested to address the problem from public policy, seeking greater equity in health care, to try to reduce the probabilities of mortality from the disease. Covid-19 and other diseases, prioritizing the most socially vulnerable group.