Discovery of spirooxindole-derived small-molecule compounds as novel HDAC/MDM2 dual inhibitors and investigation of their anticancer activity (vol 12, 972372, 2022)

被引：0
|
作者：
Zhao, Qian [1 ]
Xiong, Shan-Shan [2 ,3 ]
Chen, Can [4 ,5 ]
Zhu, Hong-Ping [1 ,6 ]
Xie, Xin [1 ]
Peng, Cheng [1 ]
He, Gu [2 ,3 ]
Han, Bo [1 ]
机构：
[1] Hosp Chengdu Univ Tradit Chinese Med, Chengdu Univ Tradit Chinese Med, Sch Basic Med Sci, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China
[2] Sichuan Univ, West China Hosp, Dept Dermatol, Chengdu, Peoples R China
[3] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu, Peoples R China
[4] Chengdu Med Coll, Sch Pharm, Chengdu, Peoples R China
[5] First Affiliated Hosp, Affiliated Hosp 1, Chengdu, Peoples R China
[6] Chengdu Univ, Sichuan Ind Inst Antibiot, Antibiot Res & Reevaluat Key Lab Sichuan Prov, Chengdu, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2023年 / 13卷
关键词：
multitarget drugs; histone deacetylase inhibitors; MDM2; inhibitors; spirooxindole; dual inhibitors; anticancer;
D O I：
10.3389/fonc.2023.1259550
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页数：3
相关论文
共 9 条
  • [1] Discovery of spirooxindole-derived small-molecule compounds as novel HDAC/MDM2 dual inhibitors and investigation of their anticancer activity
    Zhao, Qian
    Xiong, Shan-Shan
    Chen, Can
    Zhu, Hong-Ping
    Xie, Xin
    Peng, Cheng
    He, Gu
    Han, Bo
    FRONTIERS IN ONCOLOGY, 2022, 12
  • [2] Small-molecule inhibitors of MDM2 as new anticancer therapeutics
    Dickens, Michael P.
    Fitzgerald, Ross
    Fischer, Peter M.
    SEMINARS IN CANCER BIOLOGY, 2010, 20 (01) : 10 - 18
  • [3] Dual targeting of MDM2 with a novel small-molecule inhibitor overcomes TRAIL resistance in cancer
    Singh, Anup Kumar
    Chauhan, Shikha S.
    Singh, Sudhir Kumar
    Verma, Ved Vrat
    Singh, Akhilesh
    Arya, Rakesh Kumar
    Maheshwari, Shrankhla
    Akhtar, Md. Sohail
    Sarkar, Jayanta
    Rangnekar, Vivek M.
    Chauhan, Prem M. S.
    Datta, Dipak
    CARCINOGENESIS, 2016, 37 (11) : 1027 - 1040
  • [4] Design, synthesis and biological evaluation of novel potent MDM2/p53 small-molecule inhibitors
    Ivanenkov, Yan A.
    Vasilevski, Sergei V.
    Beloglazkina, Elena K.
    Kukushkin, Maksim E.
    Machulkin, Alexey E.
    Veselov, Mark S.
    Chufarova, Nina V.
    Chernyaginab, Elizaveta S.
    Vanzcool, Anton S.
    Zyk, Nikolay V.
    Skvortsov, Dmitry A.
    Khutornenko, Anastasia A.
    Rusanov, Alexander L.
    Tonevitsky, Alexander G.
    Dontsova, Olga A.
    Majouga, Alexander G.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (02) : 404 - 409
  • [5] Discovery of Novel Antitumor Small-Molecule Agent with Dual Action of CDK2/p-RB and MDM2/p53
    Liu, Zhaofeng
    Yang, Yifei
    Sun, Xiaohui
    Ma, Runchen
    Zhang, Wenjing
    Wang, Wenyan
    Yang, Gangqiang
    Wang, Hongbo
    Zhang, Jianzhao
    Wang, Yunjie
    Tian, Jingwei
    MOLECULES, 2024, 29 (03):
  • [6] KT-253, a Novel MDM2 Degrader and p53 Stabilizer, Has Superior Potency and Efficacy than MDM2 Small-Molecule Inhibitors
    Chutake, Yogesh K.
    Mayo, Michele F.
    Dumont, Nancy
    Filiatrault, Jessica
    Breitkopf, Susanne B.
    Cho, Patricia
    Chen, Dapeng
    Dixit, Vaishali S.
    Proctor, William R.
    Kuhn, Eric W.
    Martinez, Sarah Bollinger
    Mcdonald, Alice A.
    Qi, Jianfeng
    Hu, Kan-Nian
    Karnik, Rahul
    Growney, Joseph D.
    Sharma, Kirti
    Schalm, Stefanie S.
    Gollerkeri, Ashwin M.
    Mainolfi, Nello
    Williams, Juliet A.
    Weiss, Matthew M.
    MOLECULAR CANCER THERAPEUTICS, 2025, 24 (04) : 497 - 510
  • [7] Structure-based Design of Dual Small-Molecule Inhibitors of Mdm2/Mdmx for Efficiently Reactivating P53 in Cancer Cells
    Su, Zhengding
    Duda, David
    Qin, Lingyun
    Chen, Yao
    Zhang, Huashan
    Wang, Weiping
    Schulman, Brenda
    PROTEIN SCIENCE, 2014, 23 : 81 - 81
  • [8] DIMP53-1: a novel small-molecule dual inhibitor of p53-MDM2/X interactions with multifunctional p53-dependent anticancer properties
    Soares, Joana
    Espadinha, Margarida
    Raimundo, Liliana
    Ramos, Helena
    Gomes, Ana Sara
    Gomes, Sara
    Loureiro, Joana B.
    Inga, Alberto
    Reis, Flavio
    Gomes, Celia
    Santos, Maria M. M.
    Saraiva, Lucilia
    MOLECULAR ONCOLOGY, 2017, 11 (06): : 612 - 627
  • [9] Design, synthesis and in vitro and in vivo antitumour activity of 3-benzylideneindolin-2-one derivatives, a novel class of small-molecule inhibitors of the MDM2-p53 interaction
    Zheng, Guang-hui
    Shen, Jia-jia
    Zhan, Yue-chen
    Yi, Hong
    Xue, Si-tu
    Wang, Zhen
    Ji, Xing-yue
    Li, Zhuo-rong
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 81 : 277 - 288
1