Translation Inhibition through eIF4A1 Targeting in Multiple Myeloma Is a Promising Therapeutic Strategy

被引:0
|
作者
Dutrieux, Laure [1 ]
Loughran, Elle [2 ,3 ]
Choquet, Armelle [4 ]
Herault, Helene [4 ]
Guillemin, Antoine [1 ]
Robert, Nicolas [5 ]
Requirand, Guilhem [5 ]
Cartron, Guillaume [6 ,7 ,8 ]
Vincent, Laure [9 ]
Herbaux, Charles [10 ,11 ,12 ]
Rivals, Eric [2 ]
David, Alexandre [4 ]
Moreaux, Jerome [1 ,5 ,12 ,13 ,14 ,15 ,16 ]
机构
[1] Inst Genet Humaine, Montpellier, France
[2] LIRMM, Montpellier, France
[3] Trin Coll, Dublin, Ireland
[4] Inst Genet Fonctionnelle, Montpellier, France
[5] Montpellier Univ Hosp Ctr, Dept Biol Hematol, Lab Monitoring Innovat Therapies, Montpellier, France
[6] Montpellier Univ Hosp Ctr, Dept Biol Hematol, Montpellier, France
[7] Montpellier Univ Hosp Ctr, Clin Hematol Dept, Montpellier, France
[8] Univ Montpellier, IGMM UMR 5535 CNRS UM, Montpellier, France
[9] Montpellier Univ Hosp Ctr, Dept Clin Hematol, Montpellier, France
[10] Univ Montpellier, Fac Med, Montpellier, France
[11] Montpellier Univ Hosp, Dept Clin Hematol, Montpellier, France
[12] Univ Montpellier, CNRS UMR, Inst Human Genet, Montpellier, France
[13] Univ Med, Fac Med, Montpellier, France
[14] Inst Univ France, Paris, France
[15] Montpellier Univ Hosp, Dept Biol Hematol, Lab Monitoring Innovat Therapies, Montpellier, France
[16] Univ Montpellier, Montpellier, France
关键词
D O I
10.1182/blood-2023-184749
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页数:4
相关论文
共 50 条
  • [31] Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma
    Tai, Yu-Tzu
    Chang, Betty Y.
    Kong, Sun-Young
    Fulciniti, Mariateresa
    Yang, Guang
    Calle, Yolanda
    Hu, Yiguo
    Lin, Jianhong
    Zhao, Jian-Jun
    Cagnetta, Antonia
    Cea, Michele
    Sellitto, Michael A.
    Zhong, Mike Y.
    Wang, Qiuju
    Acharya, Chirag
    Carrasco, Daniel R.
    Buggy, Joseph J.
    Elias, Laurence
    Treon, Steven P.
    Matsui, William
    Richardson, Paul
    Munshi, Nikhil C.
    Anderson, Kenneth C.
    BLOOD, 2012, 120 (09) : 1877 - 1887
  • [32] eIF4A1 enhances LARP1-mediated translational repression during mTORC1 inhibition
    Shichino, Yuichi
    Yamaguchi, Tomokazu
    Kashiwagi, Kazuhiro
    Mito, Mari
    Takahashi, Mari
    Ito, Takuhiro
    Ingolia, Nicholas T.
    Kuba, Keiji
    Iwasaki, Shintaro
    NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2024, 31 (10) : 1557 - 1566
  • [33] Targeting GCK in RAS-mutant multiple myeloma offer a promising therapeutic approach
    Li, Shirong
    Fu, Jing
    Yang, Jun
    Ma, Huihui
    Mapara, Markus
    Marcireau, Christophe
    Lentzsch, Suzanne
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2021, 21 : S20 - S21
  • [34] Targeting Overexpressed IDO on Stromal Cells As a Potential Therapeutic Strategy in Multiple Myeloma
    Ebina, Toru
    Ri, Masaki
    Oshima, Yoshiko
    Nakamura, Tomoyuki
    Marumo, Yoshiaki
    Sasaki, Hirokazu
    Asano, Arisa
    Kinoshita, Shiori
    Suzuki, Tomotaka
    Narita, Tomoko
    Masaki, Ayako
    Sanda, Takaomi
    Komatsu, Hirokazu
    Sakuraba, Hirotake
    Iida, Shinsuke
    BLOOD, 2024, 144
  • [35] Translation initiation factor eIF4F modifies the dexamethasone response in multiple myeloma
    Robert, Francis
    Roman, William
    Bramoulle, Alexandre
    Fellmann, Christof
    Roulston, Anne
    Shustik, Chaim
    Porco, John A., Jr.
    Shore, Gordon C.
    Sebag, Michael
    Pelletier, Jerry
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (37) : 13421 - 13426
  • [36] Targeting PDE4 as a promising therapeutic strategy in chronic ulcerative colitis through modulating mucosal homeostasis
    Li, Heng
    Zhang, Yao
    Liu, Moting
    Fan, Chen
    Feng, Chunlan
    Lu, Qiukai
    Xiang, Caigui
    Lu, Huimin
    Yang, Xiaoqian
    Wu, Bing
    Zou, Duowu
    Tang, Wei
    ACTA PHARMACEUTICA SINICA B, 2022, 12 (01) : 228 - 245
  • [37] Targeting PDE4 as a promising therapeutic strategy in chronic ulcerative colitis through modulating mucosal homeostasis
    Heng Li
    Yao Zhang
    Moting Liu
    Chen Fan
    Chunlan Feng
    Qiukai Lu
    Caigui Xiang
    Huimin Lu
    Xiaoqian Yang
    Bing Wu
    Duowu Zou
    Wei Tang
    Acta Pharmaceutica Sinica B, 2022, 12 (01) : 228 - 245
  • [38] Role and Therapeutic Targeting of SDF-1α/CXCR4 Axis in Multiple Myeloma
    Ito, Shigeki
    Sato, Tsuyoshi
    Maeta, Takahiro
    CANCERS, 2021, 13 (08)
  • [39] The Translation Initiation Factor eIF4E Is Overexpressed in Multiple Myeloma and Is Critical for Myeloma Cell Proliferation and Survival
    Li, Shirong
    Jin, MeiHua
    Liu, Ailing
    Mapara, Markus Y.
    Lentzsch, Suzanne
    BLOOD, 2011, 118 (21) : 806 - 807
  • [40] Targeted Inhibition of Myeloperoxidase (MPO): A New Therapeutic Strategy for the Treatment of Multiple Myeloma
    Williams, Connor
    Noll, Jacqueline
    Harnas, Dylan
    Parkinson, Hayley
    Hewett, Duncan
    Wyllie, Kaitlin
    Cox, Thomas
    Zannettino, Andrew
    Vandyke, Kate
    Panagopoulos, Vasilios
    BLOOD, 2023, 142