Recent advances in dual-drug co-amorphous systems

被引：9
作者：
Shelke, Rutuja [1 ]
Velagacherla, Varalakshmi [1 ]
Nayak, Usha Yogendra [1 ]
机构：
[1] Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Dept Pharmaceut, Manipal 576104, Karnataka, India
来源：
DRUG DISCOVERY TODAY | 2024年 / 29卷 / 02期
关键词：
solubility; co-amorphous systems; dual-drug co-amorphous systems; molecular modelling; crystalline drugs; stability; amorphous drugs; docking models; crystalline inhibitors; IN-VIVO BIOAVAILABILITY; PHYSICOCHEMICAL PROPERTIES; PHYSICAL STABILITY; ENHANCED DISSOLUTION; ORAL BIOAVAILABILITY; COAMORPHOUS SYSTEM; DELIVERY SYSTEMS; CLASSIFICATION; COMBINATIONS; RITONAVIR;
D O I：
10.1016/j.drudis.2023.103863
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Poor solubility of drugs and therapeutic candidates poses a significant challenge in drug research and development. Biopharmaceutical class II drugs exhibit limited absorption because of their weak solubility and high permeability. Co-amorphous systems (CAMs) have been studied widely as a way to improve the solubility of drugs. This review summarizes recent advancements in dual-drug CAMs, including improvements in formulation, manufacturing, and solid-state characterization, and highlights the importance of enhancing solubility and stability. It emphasizes the potential synergistic effects of two drugs in CAMs and explores formulation strategies and challenges related to maintaining the amorphous state. Case studies demonstrate the successful application of CAMs in combination therapies that offer improved therapeutic efficacy.
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页数：14
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共 51 条
  • [1] Enhanced dissolution of valsartan-vanillin binary co-amorphous system loaded in mesoporous silica particles
    Ali, Khan Hashim
    Ansari, Muhammad Mohsin
    Shah, Fawad Ali
    Din, Fakhar Ud
    Basit, Muhammad Abdul
    Kim, Jin-Ki
    Zeb, Alam
    [J]. JOURNAL OF MICROENCAPSULATION, 2019, 36 (01) : 10 - 20
  • [2] Dual-drug amorphous formulation of gliclazide
    Aljohani, Marwah
    McArdle, Patrick
    Erxleben, Andrea
    [J]. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2021, 47 (02) : 302 - 307
  • [3] A THEORETICAL BASIS FOR A BIOPHARMACEUTIC DRUG CLASSIFICATION - THE CORRELATION OF IN-VITRO DRUG PRODUCT DISSOLUTION AND IN-VIVO BIOAVAILABILITY
    AMIDON, GL
    LENNERNAS, H
    SHAH, VP
    CRISON, JR
    [J]. PHARMACEUTICAL RESEARCH, 1995, 12 (03) : 413 - 420
  • [4] Preparation and recrystallization behavior of spray-dried co-amorphous naproxen-indomethacin
    Beyer, Andreas
    Radi, Lydia
    Grohganz, Holger
    Lobmann, Korbinian
    Rades, Thomas
    Leopold, Claudia S.
    [J]. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2016, 104 : 72 - 81
  • [5] The biopharmaceutics classification system (BCS): Class III drugs - better candidates for BA/BE waiver?
    Blume, HH
    Schug, BS
    [J]. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 1999, 9 (02) : 117 - 121
  • [6] Brown A., 2017, J Pharm Sci, V106, P1216
  • [7] Co amorphous systems: A product development perspective
    Chavan, Rahul B.
    Thipparaboina, Rajesh
    Kumar, Dinesh
    Shastri, Nalini R.
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2016, 515 (1-2) : 403 - 415
  • [8] Co-amorphous systems using epigallocatechin-3-gallate as a co-former: Stability, in vitro dissolution, in vivo bioavailability and underlying molecular mechanisms
    Chen, Jinfeng
    Li, Huaning
    Li, Xiangwei
    Yuan, Dandan
    Cheng, Hongqing
    Ke, Yixin
    Cheng, Jianming
    Wang, Zengwu
    Chen, Jing
    Li, Junsong
    [J]. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2022, 178 : 82 - 93
  • [9] Characterization of co-amorphous sinomenine-tranilast systems with strong intermolecular interactions and sustained release profiles
    Chen, Xin
    Li, Duanxiu
    Duan, Yanwen
    Huang, Yong
    [J]. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2022, 71
  • [10] Fabrication, solid state characterization and bioavailability assessment of stable binary amorphous phases of Ritonavir with Quercetin
    Dengale, Swapnil J.
    Hussen, Syed Sajjad
    Krishna, B. S. M.
    Musmade, Prashant B.
    Shenoy, G. Gautham
    Bhat, Krishnamurthy
    [J]. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2015, 89 : 329 - 338
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