Individual and joint associations of urinary phthalate metabolites with polycystic ovary and polycystic ovary syndrome: Results from the TREE cohort

被引：3

作者：

Zhang, Min ^{[1
,2
,3
,4
]}

Liu, Chong ^{[1
,2
,3
,4
]}

Yuan, Xiao-Qiong ^{[5
]}

Cui, Fei-Peng ^{[1
,2
,3
,4
]}

Miao, Yu ^{[1
,2
,3
,4
]}

Yao, Wen ^{[3
,4
,5
]}

Qin, Dan-Yu ^{[5
]}

Deng, Yan-Ling ^{[1
,2
,3
,4
]}

Chen, Pan-Pan ^{[1
,2
,3
,4
]}

Zeng, Jia-Yue ^{[1
,2
,3
,4
]}

Liu, Xiao-Ying ^{[1
,2
,3
,4
]}

Wu, Yang ^{[1
,2
,3
,4
]}

Li, Cheng-Ru ^{[1
,2
,3
,4
]}

Lu, Wen-Qing ^{[1
,2
,3
,4
]}

Li, Yu-Feng ^{[5
]}

Zeng, Qiang ^{[1
,2
,3
,4
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Occupat & Environm Hlth, Wuhan, Hubei, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Key Lab Environm & Hlth,Minist Educ, Wuhan, Hubei, Peoples R China

[3] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Minist Environm Protect, Wuhan, Hubei, Peoples R China

[4] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, State Key Lab Environm Hlth incubating, Wuhan, Hubei, Peoples R China

[5] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Reprod Med Ctr, 1095 Jiefang Ave, Wuhan, Peoples R China

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2023年 / 102卷

基金：

中国国家自然科学基金;

关键词：

Phthalates; Polycystic ovary; Polycystic ovary syndrome; Phthalate metabolite mixture; EXPOSURE; INSULIN; HYPERANDROGENISM; PATHOGENESIS; PREVALENCE; MECHANISMS; TOXICITY; ETIOLOGY; CRITERIA;

D O I：

10.1016/j.etap.2023.104233

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Phthalates are widespread endocrine disrupting chemicals that adversely affect female reproductive health. We aimed to investigate the individual and joint associations of phthalate exposures measured by repeated urinary metabolites with polycystic ovary (PCO) and polycystic ovary syndrome (PCOS) (96 PCO cases, 96 PCOS cases and 370 controls). In single-pollutant analyses, mono-isobutyl phthalate (MiBP), monobenzyl phthalate (MBzP) and the sum of di(2-ethylhexyl) phthalate ( n-ary sumation DEHP) were associated with increased prevalence of PCO. Mono(2-ethylhexyl) phthalate (MEHP), MBzP and n-ary sumation DEHP were associated with elevated prevalence of PCOS. In multiple-pollutant analyses, one-quartile increase of weighted quantile sum index in phthalate metabolite mixtures was associated with increased prevalence of PCO and PCOS, and MBzP was the most major contributor. Our findings suggest a potential role for phthalate exposures, both individually and in mixtures, in the devel-opment of PCO and PCOS.

引用

页数：8

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