Sex differences in the association of sleep spindle density and cognitive performance among community-dwelling middle-aged and older adults with obstructive sleep apnea

被引：1

作者：

Pun, Matiram ^{[1
,2
,3
]}

Guadagni, Veronica ^{[1
,2
,3
,4
]}

Longman, Richard Stewart ^{[2
,5
]}

Hanly, Patrick J. ^{[6
,7
]}

Hill, Michael D. ^{[2
,3
,4
,6
]}

Anderson, Todd J. ^{[8
,9
]}

Hogan, David B. ^{[2
,3
,4
,6
]}

Rawling, Jean M. ^{[10
]}

Poulin, Marc ^{[1
,2
,3
,4
,9
,11
,12
]}

机构：

[1] Univ Calgary, Cumming Sch Med, Dept Physiol & Pharmacol, Calgary, AB, Canada

[2] Univ Calgary, Hotchkiss Brain Inst, Cumming Sch Med, Calgary, AB, Canada

[3] Univ Calgary, Cumming Sch Med, Dept Clin Neurosci, Calgary, AB, Canada

[4] Univ Calgary, OBrien Inst Publ Hlth, Cumming Sch Med, Calgary, AB, Canada

[5] Alberta Hlth Serv, Foothills Med Ctr, Psychol Serv, Calgary, AB, Canada

[6] Univ Calgary, Cumming Sch Med, Dept Med, Calgary, AB, Canada

[7] Foothills Med Ctr, Sleep Ctr, Calgary, AB, Canada

[8] Univ Calgary, Cumming Sch Med, Dept Cardiac Sci, Calgary, AB, Canada

[9] Univ Calgary, Libin Cardiovasc Inst Alberta, Cumming Sch Med, Calgary, AB, Canada

[10] Univ Calgary, Cumming Sch Med, Dept Family Med, Calgary, AB, Canada

[11] Univ Calgary, Fac Kinesiol, Calgary, AB, Canada

[12] Univ Calgary, Hotchkiss Brain Inst, Cumming Sch Med, Dept Physiol & Pharmacol, Heritage Med Res Bldg Room 210,3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada

来源：

JOURNAL OF SLEEP RESEARCH | 2024年 / 33卷 / 04期

基金：

加拿大健康研究院;

关键词：

aging; cognition; community-dwelling; obstructive sleep apnea; older adults; polysomnography; sleep apnea; sleep; spindles; MENSTRUAL-CYCLE; MEMORY; CONSOLIDATION; ACCURACY; INSOMNIA; DECLINE;

D O I：

10.1111/jsr.14095

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Recent studies have found associations between obstructive sleep apnea and cognitive decline. The underlying mechanisms are still unclear. Here, we investigate the associations between changes in micro-architecture, specifically sleep spindles, and cognitive function in community-dwelling middle-aged and older adults, some with obstructive sleep apnea, with a focus on sex differences. A total of 125 voluntary participants (mean age 66.0 +/- 6.4 years, 64 females) from a larger cohort (participants of the Brain in Motion Studies I and II) underwent 1 night of in-home polysomnography and a neuropsychological battery (sleep and cognitive testing were conducted within 2 weeks of each other). A semi-automatic computerized algorithm was used to score polysomnography data and detect spindle characteristics in non-rapid eye movement Stages 2 and 3 in both frontal and central electrodes. Based on their apnea-hypopnea index, participants were divided into those with no obstructive sleep apnea (apnea-hypopnea index < 5 per hr, n = 21), mild obstructive sleep apnea (5 >_ apnea-hypopnea index < 15, n = 47), moderate obstructive sleep apnea (15 >= apnea-hypopnea index < 30, n = 34) and severe obstructive sleep apnea (apnea-hypopnea index >= 30, n = 23). There were no significant differences in spindle characteristics between the four obstructive sleep apnea severity groups. Spindle density and percentage of fast spindles were positively associated with some verbal fluency measures on the cognitive testing. Sex might be linked with these associations. Biological sex could play a role in the associations between spindle characteristics and some verbal fluency measures. Obstructive sleep apnea severity was not found to be a contributing factor in this non clinical community-dwelling cohort.

引用

页数：13