MDMA-assisted psychotherapy for PTSD: Growing evidence for memory effects mediating treatment efficacy

被引：9

作者：

Sarmanlu, Mesud ^{[1
,2
]}

Kuypers, Kim P. C. ^{[3
]}

Vizeli, Patrick ^{[4
]}

Kvamme, Timo L. ^{[5
]}

机构：

[1] Capital Reg Denmark, Mental Hlth Serv, Child & Adolescent Mental Hlth Ctr, Copenhagen, Denmark

[2] Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark

[3] Maastricht Univ, Fac Psychol & Neurosci, Dept Neuropsychol & Psychopharmacol, Maastricht, Netherlands

[4] Univ Calif San Diego, Dept Psychiat, San Diego, CA USA

[5] Aarhus Univ, Ctr Alcohol & Drug Res, Aarhus, Denmark

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2024年 / 128卷

关键词：

PTSD; trauma; MDMA; psychotherapy; memory; POSTTRAUMATIC-STRESS-DISORDER; NEUROTROPHIC FACTOR EXPRESSION; TO-SAMPLE PERFORMANCE; 3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA; AUTOBIOGRAPHICAL MEMORIES; TRAUMATIC EVENTS; GENE-EXPRESSION; OXYTOCIN CONCENTRATIONS; SEROTONIN TRANSPORTERS; INVOLUNTARY MEMORIES;

D O I：

10.1016/j.pnpbp.2023.110843

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The application of MDMA in conjunction with psychotherapy has in recent years seen a resurgence of clinical, scientific, and public interest in the treatment of posttraumatic stress disorder (PTSD). Clinical trials have shown promising safety and efficacy, but the mechanisms underlying this treatment form remain largely unestablished. This article explores recent preclinical and clinical evidence suggesting that the treatment's efficacy may be influenced by the mnemonic effects of MDMA. We review data on the effects of MDMA on fear extinction and fear reconsolidation and the utility of these processes for PTSD treatment. We corroborate our findings by incorporating research from cognitive psychology and psychopharmacology and offer recommendations for future research.

引用

页数：17

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