Irradiation-induced IFN-type-I pathway activation in prostate cancer cell lines

被引：3
作者：
Xanthopoulou, Erasmia T. [1 ]
Koukourakis, Ioannis M. [2 ]
Kakouratos, Christos [1 ]
Nanos, Christos [1 ]
Kalaitzis, Christos [3 ]
Giatromanolaki, Alexandra [4 ]
Koukourakis, Michael I. [1 ]
机构：
[1] Democritus Univ Thrace, Dept Radiotherapy Oncol, POB 12, Alexandroupolis 68100, Greece
[2] Aretaie Univ Hosp, Neonatol Unit, Athens, Greece
[3] Democritus Univ Thrace, Dept Urol, Alexandroupolis 68100, Greece
[4] Democritus Univ Thrace, Dept Pathol, Alaxandroupolis 68100, Greece
来源：
CYTOKINE | 2023年 / 169卷
关键词：
Prostate cancer; Radiotherapy; Type-I Interferon Pathway; IFN-stimulated genes; RADIOTHERAPY; INTERFERON;
D O I：
10.1016/j.cyto.2023.156252
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Interferon (CYRILLIC CAPITAL LETTER BYELORUSSIAN-UKRAINIAN IFN) Type-I pathway has an important role in the activation of an anti-tumor immune response. We investigated the effects of two different dose fractionations of radiation (3 daily 8 Gy fractions vs. one fraction of 20 Gy) on the activation of the Type-I IFN-pathway in three hormone-dependent (22Rv1) and independent (DU145, PC3), prostate cancer (PC) cell lines. Regardless of the dose schedules, radiation-induced the expression of IFN-stimulated genes in all PC cell lines, with a strong up-regulation of the IFI6v2 and IFI44 genes. In addition, strong up-regulation of the MX1 and MX2 genes was noted in the PC3 cell line. This effect was independent of the expression of IFN & beta;, cGAS, or TREX1 levels. It is suggested that the RT-induced IFN type-I response could be exploited for the development of immuno-RT policies for localized and metastatic PC.
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页数：5
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