Tumour-associated macrophages in gastric cancer: From function and mechanism to application

被引：39

作者：

Li, Jie ^{[1
]}

Sun, Juan ^{[1
]}

Zeng, Ziyang ^{[1
]}

Liu, Zhen ^{[1
]}

Ma, Mingwei ^{[1
]}

Zheng, Zicheng ^{[1
]}

He, Yixuan ^{[1
]}

Kang, Weiming ^{[1
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Gen Surg, 1 Shuaifu Yuan, Beijing 100730, Peoples R China

来源：

CLINICAL AND TRANSLATIONAL MEDICINE | 2023年 / 13卷 / 08期

基金：

北京市自然科学基金;

关键词：

gastric cancer; immune infiltration; macrophage polarisation; prognostic prediction; tumour-associated macrophage; CELLS IMMUNOSUPPRESS MACROPHAGES; IMMUNE INFILTRATION; M2; POLARIZATION; POOR-PROGNOSIS; PROMOTES; ACTIVATION; PREDICTS; CHEMOTHERAPY; PROGRESSION; HOMEOSTASIS;

D O I：

10.1002/ctm2.1386

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BackgroundGastric cancer (GC) is a malignant tumour, with high morbidity and mortality rates worldwide. The occurrence and development of GC is a complex process involving genetic changes in tumour cells and the influence of the surrounding tumour microenvironment (TME). Accumulative evidence shows that tumour-associated macrophages (TAMs) play a vital role in GC, acting as plentiful and active infiltrating inflammatory cells in the TME. Main bodyIn this review, the different functions and mechanisms of TAMs in GC progression, including the conversion of phenotypic subtypes; promotion of tumour proliferation, invasion and migration; induction of chemoresistance; promotion of angiogenesis; modulation of immunosuppression; reprogramming of metabolism; and interaction with the microbial community are summarised. Although the role of TAMs in GC remains controversial in clinical settings, clarifying their significance in the treatment selection and prognostic prediction of GC could support optimising TAM-centred clinicaltherapy. ConclusionIn summary, we reviewed the the phenotypic polarisation, function and molecular mechanism of TAMs and their potential applications in the treatment selection and prognostic prediction of GC.

引用

页数：22

共 173 条

[81] Umbelliprenin Increases the M1/M2 Ratio of Macrophage Polarization and Improves the M1 Macrophage Activity in THP-1 Cells Cocultured with AGS Cells [J].