The spectrum of nodular lymphocyte predominant Hodgkin lymphoma: a report of the lymphoma workshop of the 20th meeting of the European Association for Haematopathology

被引：2

作者：

Hartmann, Sylvia ^{[1
]}

Dojcinov, Stefan ^{[2
]}

Dotlic, Snjezana ^{[3
]}

Gibson, Sarah E. ^{[4
]}

Hsi, Eric D. ^{[5
]}

Klapper, Wolfram ^{[6
,7
]}

Klimkowska, Monika ^{[8
]}

Pinilla, Socorro Maria Rodriguez ^{[9
]}

Richter, Julia ^{[6
,7
]}

Sabattini, Elena ^{[10
]}

Tousseyn, Thomas ^{[11
,12
]}

de Jong, Daphne ^{[13
]}

机构：

[1] Goethe Univ Frankfurt Main, Dr Senckenberg Inst Pathol, Frankfurt, Germany

[2] Swansea Bay Univ Hlth Board, Morriston Hosp, Dept Pathol, Swansea, W Glam, Wales

[3] Univ Hosp Ctr Zagreb, Dept Pathol & Cytol, Zagreb, Croatia

[4] Mayo Clin, Dept Lab Med & Pathol, Div Hematopathol, Phoenix, AZ USA

[5] Wake Forest Univ, Dept Pathol, Sch Med, Winston Salem, NC USA

[6] Univ Hosp Schleswig Holstein, Dept Pathol, Hematopathol Sect, Campus Kiel, Kiel, Germany

[7] Lymph Node Registry, Campus Kiel, Kiel, Germany

[8] Karolinska Univ Hosp Huddinge, Dept Clin Pathol & Canc Diagnost, Stockholm, Sweden

[9] Hosp Univ Fdn Jimenez Diaz, Pathol Dept, Madrid, Spain

[10] Univ Bologna, Haematopathol Unit, IRCCS Azienda Osped, Bologna, Italy

[11] Dept Imaging & Pathol, Leuven, Belgium

[12] Translat Cell & Tissue Res Lab, Leuven, Belgium

[13] Locat VUMC, AmsterdamUMC, Dept Pathol, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands

来源：

VIRCHOWS ARCHIV | 2023年 / 483卷 / 04期

关键词：

Nodular lymphocyte predominant Hodgkin Lymphoma; T-cell; histiocyte-rich large B-cell lymphoma; Immune microenvironment; Diagnostic workshop; Gene expression profiling; TRANSFORMED GERMINAL-CENTERS; ENHANCER FACTOR 2B; PROGNOSTIC IMPACT; PARAGRANULOMA; EXPRESSION; FEATURES; DISEASE;

D O I：

10.1007/s00428-023-03554-1

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Session 4 of the 2021 European Association of Haematopathology/Society for Hematopathology Workshop focused on nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). First, the spectrum of immunophenotypic variations in NLPHL and the defining criteria for classic Hodgkin Lymphoma (CHL) were discussed. The added value of further immunophenotypic characterization of both tumor cells and microenvironment to support the differential diagnosis was presented. Next, unusual cases with combined growth patterns and evolution of morphological features over time were presented to explore the clinicopathological impact of presumed high-risk patterns. Based on a large collection of cases, the defining morphological, immunophenotypical, and gene expression features of T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) and THRLBCL-like NLPHL (pattern E) were reviewed to explore this challenging differential diagnosis and critically evaluate whether aggressive behavior and transformation of NLPHL can be predicted in practice.

引用

页码：451 / 463

页数：13

共 31 条

[1] The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms
Alaggio, Rita
Amador, Catalina
Anagnostopoulos, Ioannis
Attygalle, Ayoma D.
Araujo, Iguaracyra Barreto de Oliveira
Berti, Emilio
Bhagat, Govind
Borges, Anita Maria
Boyer, Daniel
Calaminici, Mariarita
Chadburn, Amy
Chan, John K. C.
Cheuk, Wah
Chng, Wee-Joo
Choi, John K.
Chuang, Shih-Sung
Coupland, Sarah E.
Czader, Magdalena
Dave, Sandeep S.
de Jong, Daphne
Du, Ming-Qing
Elenitoba-Johnson, Kojo S.
Ferry, Judith
Geyer, Julia
Gratzinger, Dita
Guitart, Joan
Gujral, Sumeet
Harris, Marian
Harrison, Christine J.
Hartmann, Sylvia
Hochhaus, Andreas
Jansen, Patty M.
Karube, Kennosuke
Kempf, Werner
Khoury, Joseph
Kimura, Hiroshi
Klapper, Wolfram
Kovach, Alexandra E.
Kumar, Shaji
Lazar, Alexander J.
Lazzi, Stefano
Leoncini, Lorenzo
Leung, Nelson
Leventaki, Vasiliki
Li, Xiao-Qiu
Lim, Megan S.
Liu, Wei-Ping
Louissaint, Abner, Jr.
Marcogliese, Andrea
Medeiros, L. Jeffrey
[J]. LEUKEMIA, 2022, 36 (07) : 1720 - 1748
[2] Anagnostopoulos I, 2000, BLOOD, V96, P1889
[3] The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee
Campo, Elias
Jaffe, Elaine S.
Cook, James R.
Quintanilla-Martinez, Leticia
Swerdlow, Steven H.
Anderson, Kenneth C.
Brousset, Pierre
Cerroni, Lorenzo
de Leval, Laurence
Dirnhofer, Stefan
Dogan, Ahmet
Feldman, Andrew L.
Fend, Falko
Friedberg, Jonathan W.
Gaulard, Philippe
Ghia, Paolo
Horwitz, Steven M.
King, Rebecca L.
Salles, Gilles
San-Miguel, Jesus
Seymour, John F.
Treon, Steven P.
Vose, Julie M.
Zucca, Emanuele
Advani, Ranjana
Ansell, Stephen
Au, Wing-Yan
Barrionuevo, Carlos
Bergsagel, Leif
Chan, Wing C.
Cohen, Jeffrey I.
d'Amore, Francesco
Davies, Andrew
Falini, Brunangelo
Ghobrial, Irene M.
Goodlad, John R.
Gribben, John G.
Hsi, Eric D.
Kahl, Brad S.
Kim, Won-Seog
Kumar, Shaji
LaCasce, Ann S.
Laurent, Camille
Lenz, Georg
Leonard, John P.
Link, Michael P.
Lopez-Guillermo, Armando
Mateos, Maria Victoria
Macintyre, Elizabeth
Melnick, Ari M.
[J]. BLOOD, 2022, 140 (11) : 1229 - 1253
[4] Lymphocyte-rich classical Hodgkin lymphoma (LRCHL): clinico-pathological characteristics and outcome of a rare entity
de Jong, D
Bosq, J
MacLennan, KA
Diebold, J
Audouin, J
Chasle, J
Mandard, AM
Marnay, J
Henry-Amar, M
[J]. ANNALS OF ONCOLOGY, 2006, 17 (01) : 141 - 145
[5] 3D analyses reveal T cells with activated nuclear features in T-cell/histiocyte-rich large B-cell lymphoma
Deli, Aresu Sadeghi Shoreh
Scharf, Sonja
Steiner, Yvonne
Bein, Julia
Hansmann, Martin-Leo
Hartmann, Sylvia
[J]. MODERN PATHOLOGY, 2022, 35 (10) : 1431 - 1438
[6] Relapsed and refractory nodular lymphocyte-predominant Hodgkin lymphoma: an analysis from the German Hodgkin Study Group
Eichenauer, Dennis A.
Pluetschow, Annette
Schroeder, Lena
Fuchs, Michael
Boell, Boris
von Tresckow, Bastian
Diehl, Volker
Borchmann, Peter
Engert, Andreas
[J]. BLOOD, 2018, 132 (14) : 1519 - 1525
[7] Characterization of variant patterns of nodular lymphocyte predominant Hodgkin lymphoma with immunohistologic and clinical correlation
Fan, Z
Natkunam, Y
Bair, E
Tibshirani, R
Warnke, RA
[J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2003, 27 (10) : 1346 - 1356
[8] EBV-positive nodular lymphocyte predominant Hodgkin lymphoma: a single institution experience
Fei, Fei
Kiruthiga, Kala Gnanasekaran
Younes, Sheren
Natkunam, Yasodha
[J]. HUMAN PATHOLOGY, 2022, 129 : 32 - 39
[9] Spatial signatures identify immune escape via PD-1 as a defining feature of T-cell/histiocyte-rich large B-cell lymphoma
Griffin, Gabriel K.
Weirather, Jason L.
Roemer, Margaretha G. M.
Lipschitz, Mikel
Kelley, Alyssa
Chen, Pei-Hsuan
Gusenleitner, Daniel
Jeter, Erin
Pak, Christine
Gjini, Evisa
Chapuy, Bjoern
Rosenthal, Michael H.
Xu, Jie
Chen, Benjamin J.
Sohani, Aliyah R.
Lovitch, Scott B.
Abramson, Jeremy S.
Ishizuka, Jeffrey J.
Kim, Austin, I
Jacobson, Caron A.
LaCasce, Ann S.
Fletcher, Christopher D.
Neuberg, Donna
Freeman, Gordon J.
Hodi, F. Stephen
Wright, Kyle
Ligon, Azra H.
Jacobsen, Eric D.
Armand, Philippe
Shipp, Margaret A.
Rodig, Scott J.
[J]. BLOOD, 2021, 137 (10) : 1353 - 1364
[10] Highly recurrent mutations of SGK1, DUSP2 and JUNB in nodular lymphocyte predominant Hodgkin lymphoma
Hartmann, S.
Schuhmacher, B.
Rausch, T.
Fuller, L.
Doering, C.
Weniger, M.
Lollies, A.
Weiser, C.
Thurner, L.
Rengstl, B.
Brunnberg, U.
Vornanen, M.
Pfreundschuh, M.
Benes, V.
Kueppers, R.
Newrzela, S.
Hansmann, M-L
[J]. LEUKEMIA, 2016, 30 (04) : 844 - 853

← 1 2 3 4 →