MicroRNA dysregulation and therapeutic opportunities in esophageal diseases

被引:6
作者
Markey, Gary E.
Donohoe, Claire L. [1 ,2 ]
McNamee, Eoin N. [3 ]
Masterson, Joanne C. [1 ,4 ]
机构
[1] Maynooth Univ, Kathleen Lonsdale Inst Human Hlth Res, Dept Biol, Allergy Inflammat & Remodelling Res Lab, Maynooth, Ireland
[2] St Jamess Hosp Dublin, Trinity St Jamess Canc Inst, Natl Esophageal & Gastr Ctr, Dublin, Ireland
[3] Maynooth Univ, Kathleen Lonsdale Inst Human Hlth Res, Dept Biol, Mucosal Immunol Res Lab, Maynooth, Ireland
[4] Univ Colorado, Childrens Hosp Colorado, Digest Hlth Inst, Dept Pediat,Sch Med,Gastrointestinal Eosinophil Di, Aurora, CO 80045 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | 2023年 / 325卷 / 01期
基金
爱尔兰科学基金会;
关键词
eosinophilic esophagitis; esophageal adenocarcinoma; esophagus; gastroesophageal reflux; microRNA; BARRETTS-ESOPHAGUS; EOSINOPHILIC ESOPHAGITIS; EXPRESSION SIGNATURES; PROGRESSION; ADENOCARCINOMA; DIAGNOSIS; MIR-375; REFLUX; ROLES; CELLS;
D O I
10.1152/ajpgi.00184.2022
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
MicroRNAs (miRNAs) are a class of small endogenous RNA molecules between 18 and 25 nucleotides long. The primary function of miRNAs is in the posttranscriptional regulation of mRNA targets through RNA interference culminating in mRNA degradation or trans-lational repression. MiRNAs are fundamental in physiological and pathological processes such as cell proliferation, differentiation, apo-ptosis, and inflammation. Among this includes the uncovered potential of miRNAs in overall esophageal disease with a focus on the clinicopathologic allergic disease eosinophilic esophagitis (EoE), gastroesophageal reflux disease (GERD), and the tumorigenic contin-uum from Barrett's esophagus (BE) toward esophageal adenocarcinoma (EAC). Although these pathologies are distinct from one another, they share pathophysiological elements such as an intense inflammatory milieu, esophageal dysfunction, and as presented in this review, an overlap in miRNA expression which contributes to overall esophageal disease. The overlap in the dysregulated miRNA transcriptome of these pathologies highlights the key role miRNAs play in contributing to esophageal disease progression. Owing to this notable dysregulation, there is an attractive utility for miRNAs as diagnostic and prognostic biomarkers in esophageal diseases that already require invasive endoscopies and biopsy retrieval. In this review miRNAs within EoE, GERD, BE, EAC, and esophageal achalasia are discussed, as well as reviewing a core set of miRNAs shared in the disease progression among some of these pathologies, along with the potential utility of targeting miRNAs as therapeutic options in overall esophageal disease.
引用
收藏
页码:G1 / G13
页数:13
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