Effects of flaxseed powder in improving non-alcoholic fatty liver by regulating gut microbiota-bile acids metabolic pathway through FXR/TGR5 mediating

被引：10
|
作者：
Yang, Chao [1 ,2 ,3 ]
Yang, Ligang [2 ,3 ,5 ]
Yang, Yafang [1 ]
Wan, Min [4 ]
Xu, Dengfeng [1 ,2 ,3 ]
Pan, Da [2 ,3 ]
Sun, Guiju [2 ,3 ]
机构：
[1] Jiangnan Univ, Wuxi Sch Med, Dept Publ Hlth & Prevent Med, Wuxi 214000, Peoples R China
[2] Southeast Univ, Sch Publ Hlth, Key Lab Environm Med & Engn, Minist Educ, Nanjing 210009, Peoples R China
[3] Southeast Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Nanjing 210009, Peoples R China
[4] Rongxiang Community Hlth Serv Ctr, Wuxi 214000, Peoples R China
[5] Southeast Univ, 87 Dingjiaqiao, Nanjing, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 163卷
基金：
中国国家自然科学基金;
关键词：
Flaxseed; Gut microbiota; Bile acid; TGR5; FXR; Non-alcoholic fatty liver; RECEPTOR; TGR5; STEATOHEPATITIS; EXPRESSION; FXR;
D O I：
10.1016/j.biopha.2023.114864
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Non-alcoholic fatty liver disease (NAFLD) is gradually becoming one of the most common and healthendangering diseases. Flaxseed powder (FLA) is rich in alpha-linolenic acid, dietary fiber, lignans, and other active ingredients, which have lipid-lowering and anti-inflammatory effects. Here, we investigated whether the FLA improves host metabolism by gut bacteria modulation and further bile acid modulation in mice fed a high-fat diet. At the end of the experiment, we found that FLA can significantly reduce the body weight, body fat content, and serum TG, LDL-C, and TNF-alpha levels of mice, and improve liver steatosis. FLA intervention has a significant effect on preventing and regulating the gut flora disturbance caused by HFD. FLA intervention affects bile acid metabolism in the intestine and causes significant changes in functional bile acids, which can play a lipidlowering and anti-inflammatory role by activating the intestinal Fxr- Fgfr4-Cyp7a1 and Tgr5-Tlr4-Tnf alpha pathways.
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页数：13
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