Procyanidin B2: A promising multi-functional food-derived pigment for human diseases

被引：48

作者：

Chen, Junren ^{[1
]}

Zhong, Kexin ^{[1
]}

Jing, Yiqi ^{[1
]}

Liu, Shengmeng ^{[1
]}

Qin, Siqi ^{[1
]}

Peng, Fu ^{[2
,3
,4
]}

Li, Dan ^{[1
,4
]}

Peng, Cheng ^{[1
,4
]}

机构：

[1] Chengdu Univ Tradit Chinese Med, State Key Lab Characterist Chinese Med Resources S, Chengdu, Peoples R China

[2] Sichuan Univ, Dept Pharmacol, Key Lab Drug Targeting & Drug Delivery Syst, Sichuan Engn Lab Plant Sourced Drug,Educ Minist, Chengdu, Peoples R China

[3] Sichuan Univ, Sichuan Res Ctr Drug Precis Ind Technol, West China Sch Pharm, Chengdu, Peoples R China

[4] Chengdu Univ Tradit Chinese Med, Sch Pharm, 37 Shierqiao Rd, Chengdu 611137, Peoples R China

来源：

FOOD CHEMISTRY | 2023年 / 420卷

基金：

中国国家自然科学基金;

关键词：

Procyanidin B2; Edible pigments; Natural sources; Bioactivities; Molecular mechanisms; ACUTE LIVER-INJURY; APOPTOSIS; PROANTHOCYANIDINS; ACTIVATION; PROTECTS; CELLS; RATS; IDENTIFICATION; PROLIFERATION; MECHANISMS;

D O I：

10.1016/j.foodchem.2023.136101

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Natural edible pigments play a paramount part in the food industry. Procyanidin B2 (PB2), one of the most representative naturally occurring edible pigments, is usually isolated from the seeds, fruits, and leaves of lots of common plants, such as grapes, Hawthorn, black soybean, as well as blueberry, and functions as a food additive in daily life. Notably, PB2 has numerous bioactivities and possesses the potential to treat/prevent a wide range of human diseases, such as diabetes mellitus, diabetic complications, atherosclerosis, and non-alcoholic fatty liver disease, and the underlying mechanisms were partially elucidated, including mediating signaling pathways like NF-kappa B, MAPK, PI3K/Akt, apoptotic axis, and Nrf-2/HO-1. This paper presents a review of the natural sources, bioactivities, and the therapeutic/preventive potential of PB2 and the possible mechanisms, with the aim of promoting the development of PB2 as a functional food and providing references for its clinical application in the treatment of diseases.

引用

页数：16

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