Development of pemphigus vegetans and exacerbation of pemphigus foliaceus after secukinumab loading in a patient with complicated generalized pustular psoriasis and pyoderma gangrenosum

被引：1

作者：

Minai, Lisa ^{[1
]}

Takeichi, Takuya ^{[2
]}

Ogawa, Youichi ^{[1
]}

Honobe-Tabuchi, Akiko ^{[1
]}

Okamoto, Takashi ^{[1
]}

Mitsui, Hiroshi ^{[1
]}

Shimada, Shinji ^{[1
]}

Akiyama, Masashi ^{[2
]}

Kawamura, Tatsuyoshi ^{[1
]}

机构：

[1] Univ Yamanashi, Dept Dermatol, Fac Med, Kofu, Yamanashi, Japan

[2] Nagoya Univ, Grad Sch Med, Dept Dermatol, Nagoya, Aichi, Japan

来源：

JOURNAL OF DERMATOLOGY | 2023年 / 50卷 / 02期

关键词：

generalized pustular psoriasis; pemphigus foliaceus; pemphigus vegetans; pyoderma gangrenosum; secukinumab;

D O I：

10.1111/1346-8138.16563

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

In dermatology, biologics that block signaling pathways of TNF-alpha, IL-4/IL13, IL-17s, and IL-23 are widely used for the treatment of several inflammatory skin diseases, such as atopic dermatitis and psoriasis. They have shown excellent efficacy with an acceptable safety profile. However, these biologics targeting pathogenic cytokines and their receptors could modulate immunological balance, leading to the development of other inflammatory or autoimmune skin diseases in some cases. In this study, we present a patient who suffered pemphigus vegetans and showed an exacerbation of pemphigus foliaceus after secukinumab loading for the treatment of complicated generalized pustular psoriasis and pyoderma gangrenosum.

引用

页码：245 / 249

页数：5