Cumulative Detection of Anal High-Grade Squamous Intraepithelial Lesions Over 2-Year Follow-up in Men Who Have Sex With Men Living With Human Immunodeficiency Virus in France

被引：0

作者：

Combes, Jean-Damien ^{[1
]}

Didelot, Jean-Michel ^{[2
]}

Radenne, Sylvie ^{[3
]}

Zaegel-Faucher, Olivia ^{[4
,5
]}

Lesage, Anne-Carole ^{[6
]}

Siproudhis, Laurent ^{[7
,8
,9
]}

Piroth, Lionel ^{[10
,11
]}

Marchand, Lucie ^{[12
]}

Heard, Isabelle ^{[13
,14
]}

Hoyeau, Nadia ^{[15
]}

Henno, Sebastien ^{[16
]}

Darragh, Teresa M. ^{[17
]}

Alberts, Catharina J. ^{[1
]}

Clifford, Gary M. ^{[1
,18
]}

Etienney, Isabelle ^{[6
]}

机构：

[1] Int Agcy Res Canc IARC WHO, Early Detect Prevent & Infect Branch, Lyon, France

[2] Ctr Hosp Univ Montpellier, Serv Hepatogastroenterol, Montpellier, France

[3] CHU Lyon, Hop Croix Rousse, Serv Hepatol, Lyon, France

[4] Univ Aix Marseille, Serv Immuno Hematol Clin, APHM St Marguer, Marseille, France

[5] Univ Aix Marseille, Sci Econ & Sociales Sante & Traitement Informat Me, INSERM U912, Marseille, France

[6] Grp Hosp Diaconesses Croix St Simon, Serv Proctol Med Intervent, Paris, France

[7] Univ Hosp Rennes, Dept Gastroenterol, Rennes, France

[8] Univ Rennes 1, Inserm U1241, Rennes, France

[9] Univ Hosp Rennes, INPHY CIC 1414, Rennes, France

[10] Ctr Hosp Univ CHU Dijon, Dept Infectiol, Dijon, France

[11] Univ Bourgogne, Inst Natl Sante & Rech Med INSERM, Ctr Invest Clin INSERM CIC INSERM 1432, Dijon, France

[12] Agence Natl Rech sida & hepat Malad infectieuses e, Paris, France

[13] Ctr Natl Reference HPV, Inst Pasteur, Paris, France

[14] Hop Tenon, AP HP, Paris, France

[15] Hop St Antoine, AP HP, Grp Hosp Hop Univ Est Parisien GH HUEP, Serv Anat & Cytol Pathol, F-75571 Paris, France

[16] CHU Pontchaillou, Serv Anat & Cytol Pathol, Rennes, France

[17] Univ Calif San Francisco, Dept Pathol, San Francisco, CA USA

[18] Int Agcy Res Canc IARC WHO, Early Detect Prevent & Infect Branch, 25 Ave Tony Garnier, F-69366 Lyon 07, France

来源：

JOURNAL OF INFECTIOUS DISEASES | 2023年 / 230卷 / 01期

关键词：

men who have sex with men; human immunodeficiency virus; anal cytology; high-resolution anoscopy; human papillomavirus; CANCER; HIV;

D O I：

10.1093/infdis/jiad506

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We assessed cumulative detection and determinants of anal high-grade squamous intraepithelial lesions (HSILs) in men who have sex with men living with human immunodeficiency virus and who underwent 3 visits over 2 years, with cytology and high-resolution anoscopy, within the ANRS-EP57-APACHES study. The cumulative HSIL detection rate was 33% (134 of 410), of which 48% HSILs were detected at baseline. HSIL detection varied considerably by center (from 13% to 51%). The strongest HSIL determinants were baseline human papillomavirus 16 (adjusted odds ratio, 8.2; 95% confidence interval, 3.6-18.9) and p16/Ki67 (4.6 [2.3-9.1]). Repeated annual cytology and high-resolution anoscopy improved HSIL detection but did not fully compensate for between-center heterogeneity. Among 410 men having sex with men living with human immunodeficiency virus and undergoing annual anal cytology and high-resolution anoscopy, 33% had high-grade anal lesions detected within 2 years; strongest determinants were baseline positivity for human papillomavirus 16 and p16/Ki67.

引用

页码：55 / 60

页数：6

共 50 条

[31] The performance of human papillomavirus biomarkers in predicting anal high-grade squamous intraepithelial lesions in gay and bisexual men
Jin, Fengyi
Roberts, Jennifer M.
Grulich, Andrew E.
Poynten, Isobel M.
Machalek, Dorothy A.
Cornall, Alyssa
Phillips, Samuel
Ekman, Deborah
McDonald, Ross L.
Hillman, Richard J.
Templeton, David J.
Farnsworth, Annabelle
Garland, Suzanne M.
Fairley, Christopher K.
Tabrizi, Sepehr N.
AIDS, 2017, 31 (09) : 1303 - 1311
[32] High-risk Human Papilloma Virus Testing Improves Diagnostic Performance to Predict Moderate- to High-grade Anal Intraepithelial Neoplasia in Human Immunodeficiency Virus-infected Men Who Have Sex With Men in Low-to-Absent Cytological Abnormalities
Viciana, Pompeyo
Milanes-Guisado, Yusnelkis
Fontillon, Maria
Dominguez Castano, Ana
Sotomayor, Cesar
Espinosa, Nuria
Lopez-Cortes, Luis F.
Neukam, Karin
CLINICAL INFECTIOUS DISEASES, 2019, 69 (12) : 2185 - 2192
[33] The Changing Picture of High-grade Anal Intraepithelial Neoplasia in Men Who Have Sex With Men: The Effects of 10 Years of Experience Performing High-resolution Anoscopy
Swedish, Kristin A.
Lee, Eric Q.
Goldstone, Stephen E.
DISEASES OF THE COLON & RECTUM, 2011, 54 (08) : 1003 - 1007
[34] Testing for high risk human papilloma virus in the initial follow-up of women treated for high-grade squamous intraepithelial lesions
Smart, Olivia Catherine
Sykes, Peter
Macnab, Helene
Jennings, Lance
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY, 2010, 50 (02) : 164 - 167
[35] The fear factor: drivers and barriers to follow-up screening for human papillomavirus-related anal cancer in men who have sex with men
Truesdale, M. D.
Goldstone, S. E.
INTERNATIONAL JOURNAL OF STD & AIDS, 2010, 21 (07) : 482 - 488
[36] Clinical effectiveness and cost-effectiveness of quadrivalent human papillomavirus vaccination in HIV-negative men who have sex with men to prevent recurrent high-grade anal intraepithelial neoplasia
Deshmukh, Ashish A.
Chiao, Elizabeth Y.
Das, Prajnan
Cantor, Scott B.
VACCINE, 2014, 32 (51) : 6941 - 6947
[37] Human Papillomavirus Detection by PCR Assay in a Large Series of High-Grade Squamous Intraepithelial Lesions with Cytohistological Correlation and Follow-Up
Lerma Puertas, Enrique
Otal Salaverri, Concepcion
Rios Martin, Juan Jose
Sanchez Gomez, Ana
Jimenez Caraballo, Antonio
Gonzalez-Campora, Ricardo
ACTA CYTOLOGICA, 2011, 55 (05) : 426 - 432
[38] Infrared coagulator ablation of high-grade anal squamous intraepithelial lesions in HIV-negative males who have sex with males
Goldstone, Stephen E.
Hundert, Joshua S.
Huyett, Jeff W.
DISEASES OF THE COLON & RECTUM, 2007, 50 (05) : 565 - 575
[39] Anal squamous intraepithelial lesions are frequent among young HIV-infected men who have sex with men followed up at the Spanish AIDS Research Network Cohort (CoRIS-HPV)
Gonzalez, Cristina
Torres, Montserrat
Benito, Amparo
del Romero, Jorge
Rodriguez, Carmen
Fontillon, Maria
Trastoy, Monica
Viciana, Pompeyo
del Amo, Julia
Ortiz, Marta
Hernandez-Novoa, Beatriz
INTERNATIONAL JOURNAL OF CANCER, 2013, 133 (05) : 1164 - 1172
[40] Anal high-risk human papillomavirus infection and high-grade anal intraepithelial neoplasia detected in women and heterosexual men infected with human immunodeficiency virus
Gandra, Sumanth
Azar, Aline
Wessolossky, Mireya
HIV AIDS-RESEARCH AND PALLIATIVE CARE, 2015, 7 : 29 - 34

← 1 2 3 4 5 →