Cumulative Detection of Anal High-Grade Squamous Intraepithelial Lesions Over 2-Year Follow-up in Men Who Have Sex With Men Living With Human Immunodeficiency Virus in France

被引：0

作者：

Combes, Jean-Damien ^{[1
]}

Didelot, Jean-Michel ^{[2
]}

Radenne, Sylvie ^{[3
]}

Zaegel-Faucher, Olivia ^{[4
,5
]}

Lesage, Anne-Carole ^{[6
]}

Siproudhis, Laurent ^{[7
,8
,9
]}

Piroth, Lionel ^{[10
,11
]}

Marchand, Lucie ^{[12
]}

Heard, Isabelle ^{[13
,14
]}

Hoyeau, Nadia ^{[15
]}

Henno, Sebastien ^{[16
]}

Darragh, Teresa M. ^{[17
]}

Alberts, Catharina J. ^{[1
]}

Clifford, Gary M. ^{[1
,18
]}

Etienney, Isabelle ^{[6
]}

机构：

[1] Int Agcy Res Canc IARC WHO, Early Detect Prevent & Infect Branch, Lyon, France

[2] Ctr Hosp Univ Montpellier, Serv Hepatogastroenterol, Montpellier, France

[3] CHU Lyon, Hop Croix Rousse, Serv Hepatol, Lyon, France

[4] Univ Aix Marseille, Serv Immuno Hematol Clin, APHM St Marguer, Marseille, France

[5] Univ Aix Marseille, Sci Econ & Sociales Sante & Traitement Informat Me, INSERM U912, Marseille, France

[6] Grp Hosp Diaconesses Croix St Simon, Serv Proctol Med Intervent, Paris, France

[7] Univ Hosp Rennes, Dept Gastroenterol, Rennes, France

[8] Univ Rennes 1, Inserm U1241, Rennes, France

[9] Univ Hosp Rennes, INPHY CIC 1414, Rennes, France

[10] Ctr Hosp Univ CHU Dijon, Dept Infectiol, Dijon, France

[11] Univ Bourgogne, Inst Natl Sante & Rech Med INSERM, Ctr Invest Clin INSERM CIC INSERM 1432, Dijon, France

[12] Agence Natl Rech sida & hepat Malad infectieuses e, Paris, France

[13] Ctr Natl Reference HPV, Inst Pasteur, Paris, France

[14] Hop Tenon, AP HP, Paris, France

[15] Hop St Antoine, AP HP, Grp Hosp Hop Univ Est Parisien GH HUEP, Serv Anat & Cytol Pathol, F-75571 Paris, France

[16] CHU Pontchaillou, Serv Anat & Cytol Pathol, Rennes, France

[17] Univ Calif San Francisco, Dept Pathol, San Francisco, CA USA

[18] Int Agcy Res Canc IARC WHO, Early Detect Prevent & Infect Branch, 25 Ave Tony Garnier, F-69366 Lyon 07, France

来源：

JOURNAL OF INFECTIOUS DISEASES | 2023年 / 230卷 / 01期

关键词：

men who have sex with men; human immunodeficiency virus; anal cytology; high-resolution anoscopy; human papillomavirus; CANCER; HIV;

D O I：

10.1093/infdis/jiad506

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We assessed cumulative detection and determinants of anal high-grade squamous intraepithelial lesions (HSILs) in men who have sex with men living with human immunodeficiency virus and who underwent 3 visits over 2 years, with cytology and high-resolution anoscopy, within the ANRS-EP57-APACHES study. The cumulative HSIL detection rate was 33% (134 of 410), of which 48% HSILs were detected at baseline. HSIL detection varied considerably by center (from 13% to 51%). The strongest HSIL determinants were baseline human papillomavirus 16 (adjusted odds ratio, 8.2; 95% confidence interval, 3.6-18.9) and p16/Ki67 (4.6 [2.3-9.1]). Repeated annual cytology and high-resolution anoscopy improved HSIL detection but did not fully compensate for between-center heterogeneity. Among 410 men having sex with men living with human immunodeficiency virus and undergoing annual anal cytology and high-resolution anoscopy, 33% had high-grade anal lesions detected within 2 years; strongest determinants were baseline positivity for human papillomavirus 16 and p16/Ki67.

引用

页码：55 / 60

页数：6

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