Natalizumab Treatment for Relapsing Multiple Sclerosis Stabilises Normal-Appearing White Matter Microstructure: A One-Year Prospective Ultra-High-Field Quantitative Imaging Study

被引:1
作者
Tanasescu, Radu [1 ,2 ]
Mougin, Olivier [3 ]
Chou, I-Jun [1 ,4 ]
Al-Radaideh, Ali [3 ,5 ,6 ]
Jerca, Oltita P. [1 ,7 ]
Lim, Su-Yin [1 ,8 ]
Gowland, Penny [3 ]
Constantinescu, Cris S. [1 ,2 ,9 ]
机构
[1] Univ Nottingham, Acad Unit Mental Hlth & Clin Neurosci, Sect Clin Neurol, Nottingham NG7 2UH, England
[2] Nottingham Univ Hosp NHS Trust, Nottingham Ctr MS & Neuroinflammat, Dept Neurol, Nottingham NG5 1PB, England
[3] Univ Nottingham, Sir Peter Mansfield Imaging Ctr, Sch Phys & Astron, Nottingham NG7 2QL, England
[4] Chang Gung Mem Hosp, Linko Branch, Taoyuan 333, Taiwan
[5] Hashemite Univ, Fac Appl Med Sci, Dept Med Imaging, Zarqa 13133, Jordan
[6] Univ Doha Sci & Technol, Coll Hlth Sci, Dept Med Radiog, Doha, Qatar
[7] Med Zentrum Harz, D-38820 Halberstadt, Germany
[8] Taylors Univ, Fac Hlth & Med Sci, Sch Med, Subang Jaya 47500, Malaysia
[9] Rowan Univ, Cooper Neurol Inst, Cooper Med Sch, Camden, NJ 08013 USA
关键词
multiple sclerosis; ultra-high-field MRI; natalizumab; normal-appearing white matter; MAGNETIZATION-TRANSFER; BRAIN-TISSUE; MRI; T-1; 3T;
D O I
10.3390/brainsci13101464
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
(1) Background: Natalizumab dramatically reduces relapses and MRI inflammatory activity (new lesions and enhancing lesions) in multiple sclerosis (MS). Chemical exchange saturation transfer (CEST) MRI can explore brain tissue in vivo with high resolution and sensitivity. We investigated if natalizumab can prevent microstructural tissue damage progression measured with MRI at ultra-high field (7 Tesla) over the first year of treatment. (2) Methods: In this one-year prospective longitudinal study, patients with active relapsing-remitting MS were assessed clinically and scanned at ultra-high-field MRI at the time of their first natalizumab infusion, at 6 and 12 months, with quantitative imaging aimed to detect microstructural changes in the normal-appearing white matter (NAWM), including sequences sensitive to magnetisation transfer (MT) effects from amide proton transfer (MTRAPT) and the nuclear Overhauser effect (MTRNOE). (3) Results: 12 patients were recruited, and 10 patients completed the study. The difference in the T1 relaxation times at month 6 and month 12 of natalizumab treatment was not significant, suggesting the lack of accumulation of tissue damage, while improvements were seen in MTR (MTRAPT and MTRNOE measures) at month 12, suggesting a tissue repair effect. This paralleled the expected lack of clinical and radiological worsening of conventional MRI measures of disease activity (new lesions or gadolinium-enhancing lesions). (4) Conclusion: Natalizumab prevents microstructural brain damage and has effects suggesting an improved white matter microstructure measured at ultra-high field during the first year of treatment.
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页数:11
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