Clinicopathological patterns and outcomes of ovarian borderline tumors: A tertiary center experience

Objectives: To study clinical/ morphological parameters of ovarian borderline tumors (OBT) and outcomes at a major national center Design: Retrospective study Setting: Jordan University Hospital, Amman, Jordan Subjects: We studied 42 OBTs meeting inclusion criteria from 2009 to 2019. Interventions: Data from medical and histopathology sources were collected. Microscopic review of study cases for morphological parameters. Main outcome measures: Clinicopathological parameters and outcome were explored using descriptive statistics and correlations. Results: The mean age was 38.5 years, the 5th decade was the most common age group (38.1%), 21.4% were menopausal and mean follow up was 46 months. Surgery included fertility sparing (27; 64.3%) and non-fertility sparing procedures (15; 35.7%). The most common presentation was pain (17; 40.5%), 81% were unilateral, mean tumor diameter was 10.54 cm. Serum CA125 was elevated in 16 (38.1%). CA19.9 was elevated in 3 (7.1%). Twenty-eight were serous (66.7%) and 14 (33.3%) mucinous. FIGO stage included I (34; 81%); II (1; 2.3%), and III (7; 16.7%). Recurrence occurred in 6 (14.2%). Successful pregnancy was documented in 8 (19%). Death occurred in 4 (9.5%). Recurrences and deaths respectively were significantly correlated to higher stage (Pearson chi(2) 0.000; 0.000); positive peritoneal washings (0.002; 0.000); omental metastasis (0.000; 0.000); and residual mass post op (0.002; 0.013). Other studied parameters did not reveal significance including age, histotype, surgery type, diameter, CA125, CA19.9, lymph node status, ovarian surface involvement, lymphovascular invasion, micropapillary architecture, microinvasion and intraepithelial carcinoma. Conclusion: OBTs have excellent prognosis with low rates of recurrences and death. Conservative surgery for desired fertility preservation balanced by longterm followup is recommended.