Rosalind Franklin Society Proudly Announces the 2022 Award Recipient for Cannabis and Cannabinoid Research

?9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are major chemical constituents of cannabis, which may interact either directly or indirectly with the endocannabinoid and endocannabinoidlike systems. In this study, we describe a sensitive and accurate method for the simultaneous quantification of THC, its main oxidative metabolites [11- hydroxy-?9-THC (11-OH- THC) and 11-nor-9-carboxy-?9-THC (11-COOH-THC)], CBD, and a representative set of endocannabinoid [anandamide and 2-arachidonoyl-sn-glycerol (2-AG)] and paracannabinoid [palmitoylethanolamide (PEA) and oleoylethanolamide (OEA)] compounds. An application of the method is presented, which showed that phytocannabinoid administration elevates endocannabinoid levels in plasma and brain of adolescent male and female mice.