Engineering Au44 Nanoclusters for NIR-II Luminescence Imaging-Guided Photoactivatable Cancer Immunotherapy

被引：58
作者：
Yang, Ge [1 ]
Pan, Xinxin [1 ]
Feng, Wenbi [1 ]
Yao, Qiaofeng [2 ]
Jiang, Fuyi [3 ]
Du, Fanglin [1 ]
Zhou, Xianfeng [1 ]
Xie, Jianping [2 ,4 ]
Yuan, Xun [1 ]
机构：
[1] Qingdao Univ Sci & Technol, Sch Mat Sci & Engn, Qingdao 266042, Peoples R China
[2] Int Campus Tianjin Univ, Joint Sch Natl Univ Singapore & Tianjin Univ, Fuzhou 350207, Peoples R China
[3] Yantai Univ, Sch Environm & Mat Engn, Yantai 264005, Peoples R China
[4] Natl Univ Singapore, Dept Chem & Biomol Engn, 4 Engn Dr 4, Singapore 117585, Singapore
来源：
ACS NANO | 2023年 / 17卷 / 16期
基金：
中国国家自然科学基金;
关键词：
Au nanocluster; Ligand engineering; NIR-IIluminescence imaging; Photothermal therapy; Immunotherapy; METAL NANOCLUSTERS; GOLD;
D O I：
10.1021/acsnano.3c02370
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Immunotherapy is an advanced therapeutic strategy ofcancer treatmentbut suffers from the issues of off-target adverse effects, lack ofreal-time monitoring techniques, and unsustainable response. Herein,an ultrasmall Au nanocluster (NC)-based theranostic probe is designedfor second near-infrared window (NIR-II) photoluminescence (PL) imaging-guidedphototherapies and photoactivatable cancer immunotherapy. The probe(Au(44)MBA(26)-NLG for short) is composed of atomicallyprecise and NIR-II emitting Au(44)MBA(26) NCs (hereMBA denotes water-soluble 4-mercaptobenzoic acid) conjugated withimmune checkpoint inhibitor 1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol (NLG919) via a singlet oxygen (O-1(2))-cleavable linker. Upon NIR photoirradiation,the Au(44)MBA(26)-NLG not only enables NIR-II PLimaging of tumors in deep tissues for guiding tumor therapy but alsoallows the leverage of photothermal property for cancer photothermaltherapy (PTT) and the photogenerated O-1(2) forphotodynamic therapy (PDT) and releasing NLG919 for cancer immunotherapy.Such a multiple effect modulated by Au(44)MBA(26)-NLG prompts the proliferation and activation of effector T cells,upshifts systemic antitumor T-lymphocyte (T cell) immunity, and finallysuppresses the growth of both primary and distant tumors in livingmice. Overall, this study may provide a promising theranostic nanoplatformtoward NIR-II PL imaging-guided phototherapies and photoactivatablecancer immunotherapy.
引用
收藏
页码：15605 / 15614
页数：10
相关论文
共 55 条
[21]   Photon-Controlled Pyroptosis Activation (PhotoPyro): An Emerging Trigger for Antitumor Immune Response [J].
Li, Mingle ;
Kim, Jungryun ;
Rha, Hyeonji ;
Son, Subin ;
Levine, Matthew S. ;
Xu, Yunjie ;
Sessler, Jonathan L. ;
Kim, Jong Seung .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2023, 145 (11) :6007-6023
[22]   Emerging ultrasmall luminescent nanoprobes for in vivo bioimaging [J].
Li, Shihua ;
Wei, Jing ;
Yao, Qiaofeng ;
Song, Xiaorong ;
Xie, Jianping ;
Yang, Huanghao .
CHEMICAL SOCIETY REVIEWS, 2023, 52 (05) :1672-1696
[23]   Engineering Noble Metal Nanomaterials for Pollutant Decomposition [J].
Lin, Yingzheng ;
Cao, Yitao ;
Yao, Qiaofeng ;
Chai, Osburg Jin Huang ;
Xie, Jianping .
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 2020, 59 (47) :20561-20581
[24]   Engineering Metal Nanoclusters for Targeted Therapeutics: From Targeting Strategies to Therapeutic Applications [J].
Lin, Zhenkun ;
Goswami, Nirmal ;
Xue, Tiantian ;
Chai, Osburg Jin Huang ;
Xu, Hejie ;
Liu, Yuxin ;
Su, Yu ;
Xie, Jianping .
ADVANCED FUNCTIONAL MATERIALS, 2021, 31 (51)
[25]   Catalytically potent and selective clusterzymes for modulation of neuroinflammation through single-atom substitutions [J].
Liu, Haile ;
Li, Yonghui ;
Sun, Si ;
Xin, Qi ;
Liu, Shuhu ;
Mu, Xiaoyu ;
Yuan, Xun ;
Chen, Ke ;
Wang, Hao ;
Varga, Kalman ;
Mi, Wenbo ;
Yang, Jiang ;
Zhang, Xiao-Dong .
NATURE COMMUNICATIONS, 2021, 12 (01)
[26]   Atomic-Precision Gold Clusters for NIR-II Imaging [J].
Liu, Haile ;
Hong, Guosong ;
Luo, Zhentao ;
Chen, Junchi ;
Chang, Junlei ;
Gong, Ming ;
He, Hua ;
Yang, Jiang ;
Yuan, Xun ;
Li, Lulin ;
Mu, Xiaoyu ;
Wang, Junying ;
Mi, Wenbo ;
Luo, Jian ;
Xie, Jianping ;
Zhang, Xiao-Dong .
ADVANCED MATERIALS, 2019, 31 (46)
[27]  
Luo M, 2017, NAT NANOTECHNOL, V12, P648, DOI [10.1038/nnano.2017.52, 10.1038/NNANO.2017.52]
[28]   Engineering ultrasmall water-soluble gold and silver nanoclusters for biomedical applications [J].
Luo, Zhentao ;
Zheng, Kaiyuan ;
Xie, Jianping .
CHEMICAL COMMUNICATIONS, 2014, 50 (40) :5143-5155
[29]   Cancer immunotherapy comes of age [J].
Mellman, Ira ;
Coukos, George ;
Dranoff, Glenn .
NATURE, 2011, 480 (7378) :480-489
[30]   N-heterocyclic carbene-functionalized magic-number gold nanoclusters [J].
Narouz, Mina R. ;
Osten, Kimberly M. ;
Unsworth, Phillip J. ;
Man, Renee W. Y. ;
Salorinne, Kirsi ;
Takano, Shinjiro ;
Tomihara, Ryohei ;
Kaappa, Sami ;
Malola, Sami ;
Dinh, Cao-Thang ;
Padmos, J. Daniel ;
Ayoo, Kennedy ;
Garrett, Patrick J. ;
Nambo, Masakazu ;
Horton, J. Hugh ;
Sargent, Edward H. ;
Hakkinen, Hannu ;
Tsukuda, Tatsuya ;
Crudden, Cathleen M. .
NATURE CHEMISTRY, 2019, 11 (05) :419-425
123456