The altered metabolic pathways of diffuse large B-cell lymphoma not otherwise specified

被引：1

作者：

Rodrigues-Fernandes, Carla Isabelly ^{[1
]}

Martins-Chaves, Roberta Rayra ^{[2
]}

Vitorio, Jessica Gardone ^{[2
]}

Duarte-Andrade, Filipe Fideles ^{[2
]}

Pereira, Thais dos Santos Fontes ^{[2
]}

Soares, Ciro Dantas ^{[3
]}

Moreira, Victor Rezende ^{[4
]}

Lebron, Yuri Abner Rocha ^{[4
]}

Santos, Lucilaine Valeria de Souza ^{[4
]}

Lange, Lisete Celina ^{[4
]}

Canuto, Gisele Andre Baptista ^{[5
]}

Gomes, Carolina Cavalieri ^{[6
]}

de Macedo, Adriana Nori ^{[7
]}

Pontes, Helder Antonio Rebelo ^{[8
]}

Burbano, Rommel Mario Rodriguez ^{[8
]}

Martins, Manoela Domingues ^{[9
]}

Pires, Fabio Ramoa ^{[10
]}

Mesquita, Ricardo Alves ^{[2
]}

Gomez, Ricardo Santiago ^{[2
]}

Santos-Silva, Alan Roger ^{[1
]}

Lopes, Marcio Ajudarte ^{[1
]}

Vargas, Pablo Agustin ^{[1
]}

Fonseca, Felipe Paiva ^{[2
]}

机构：

[1] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Oral Diag Semiol & Pathol Areas, UNICAMP, Piracicaba, SP, Brazil

[2] Univ Fed Minas Gerais UFMG, Sch Dent, Dept Oral Surg & Pathol, Belo Horizonte, Brazil

[3] Getulio Sales Lab, Natal, RN, Brazil

[4] Univ Fed Minas Gerais UFMG, Sch Engn, Dept Sanitat & Environm Engn, Belo Horizonte, Brazil

[5] Univ Fed Bahia UFBA, Inst Chem, Dept Analyt Chem, Salvador, Brazil

[6] Univ Fed Minas Gerais UFMG, Biol Sci Inst, Dept Pathol, Belo Horizonte, Brazil

[7] Univ Fed Minas Gerais UFMG, Exact Sci Inst, Dept Chem, Belo Horizonte, Brazil

[8] Fed Univ Para UFPA, Joao de Barros Barreto Univ Hosp, Serv Oral Pathol, Belem, Brazil

[9] Fed Univ Rio Grande Sul UFRGS, Sch Dent, Dept Pathol, Porto Alegre, Brazil

[10] Rio de Janeiro State Univ UERJ, Dent Sch, Oral Pathol, Rio De Janeiro, Brazil

来源：

LEUKEMIA & LYMPHOMA | 2023年 / 64卷 / 11期

关键词：

Non-Hodgkin l-ymphoma; diffuse large B-cell lymphoma; metabolomics; metabolic pathways; GENE-EXPRESSION; VITAMIN-E; NATURAL FORMS; CLASSIFICATION; ANTIOXIDANT; TISSUE; ALPHA; ACTIVATION; PREVENTION; ORIGIN;

D O I：

10.1080/10428194.2023.2234523

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Altered metabolic fingerprints of Diffuse large B-cell lymphoma, not otherwise specified (DLBCL NOS) may offer novel opportunities to identify new biomarkers and improve the understanding of its pathogenesis. This study aimed to investigate the modified metabolic pathways in extranodal, germinal center B-cell (GCB) and non-GCB DLBCL NOS from the head and neck. Formalin-fixed paraffin-embedded (FFPE) tissues from eleven DLBCL NOS classified according to Hans' algorithm using immunohistochemistry, and five normal lymphoid tissues (LT) were analyzed by high-performance liquid chromatography-mass spectrometry-based untargeted metabolomics. Partial Least Squares Discriminant Analysis showed that GCB and non-GCB DLBCL NOS have a distinct metabolomics profile, being the former more similar to normal lymphoid tissues. Metabolite pathway enrichment analysis indicated the following altered pathways: arachidonic acid, tyrosine, xenobiotics, vitamin E metabolism, and vitamin A. Our findings support that GCB and non-GCB DLBCL NOS has a distinct metabolomic profile, in which GCB possibly shares more metabolic similarities with LT than non-GCB DLBCL NOS.

引用

页码：1771 / 1781

页数：11

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