Predicting membrane orientational states of RAS and RAS-RAF based on the lipid environment using deep learning

被引：0
|
作者：
Aydin, Fikret [1 ]
Georgouli, Konstantia [1 ]
Dharuman, Gautham [1 ]
Glosli, James N. [1 ]
Carpenter, Timothy S. [2 ]
Lightstone, Felice C. [3 ]
Ingolfsson, Helgi [1 ]
Bremer, Peer-Timo [1 ]
Bhatia, Harsh [1 ]
机构：
[1] Lawrence Livermore Natl Lab, Livermore, CA USA
[2] Lawrence Livermore Natl Lab, Biosci, Livermore, CA USA
[3] Lawrence Livermore Natl Lab, Phys & Life Sci, Livermore, CA USA
来源：
BIOPHYSICAL JOURNAL | 2023年 / 122卷 / 03期
关键词：
D O I：
暂无
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
2461-Pos
引用
收藏
页码：506A / 506A
页数：1
相关论文
共 50 条
  • [1] Design of inhibitors of Ras-Raf interaction using a computational combinatorial algorithm
    Zeng, J
    Nheu, T
    Zorzet, A
    Catimel, B
    Nice, E
    Maruta, H
    Burgess, AW
    Treutlein, HR
    PROTEIN ENGINEERING, 2001, 14 (01): : 39 - 45
  • [2] Massively Parallel Machine Learning Driven Multiscale Simulations to Explore RAS-RAF Biology
    Ingolfsson, Helgi I.
    BIOPHYSICAL JOURNAL, 2021, 120 (03) : 77A - 77A
  • [3] MuMMI, a machine learning-driven modeling infrastructure for coupling different simulation scales; showcased for RAS-RAF activation
    Ingolfsson, Helgi I.
    BIOPHYSICAL JOURNAL, 2023, 122 (03) : 463A - 463A
  • [4] Towards Piecing Together the RAS-RAF Puzzle: Dynamics of Membrane-Associated KRAS4b-RAF RBD/CRD Ternary Complex
    Travers, Timothy
    Lopez, Cesar A.
    Gnanakaran, S.
    BIOPHYSICAL JOURNAL, 2018, 114 (03) : 75A - 75A
  • [5] Using Machine Learning to Predict Membrane Protein States Based on their Lipid Environment
    Moody, Adam T.
    Dharuman, Gautham
    Carpenter, Timothy S.
    Ingolfsson, Helgi I.
    Van Essen, Brian C.
    Glosli, James N.
    Lightstone, Felice C.
    BIOPHYSICAL JOURNAL, 2020, 118 (03) : 497A - 497A
  • [6] Exploring protein conformational paths using machine learning-generated structures coupled to a multiscale simulation framework showcased for RAS-RAF activation
    Ingolfsson, Helgi I.
    BIOPHYSICAL JOURNAL, 2024, 123 (03) : 140A - 140A
  • [7] Change in protein flexibility upon complex formation: Analysis of Ras-Raf using molecular dynamics and a molecular framework approach
    Gohlke, H
    Kuhn, LA
    Case, DA
    PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2004, 56 (02) : 322 - 337
  • [8] Characterization of the Spatial Organization of Raf Isoforms Interacting with K-Ras4B in the Lipid Membrane
    Li, Lei
    Mobitz, Simone
    Winter, Roland
    LANGMUIR, 2020, 36 (21) : 5944 - 5953
  • [9] Signaling algorithm based on RAS-RAF and cell-cycle pathways' alterations in precision medicine: rational combination of drugs in ovarian carcinoma
    Dey, Nandini
    Williams, Casey
    Williams, Kirstin
    Klein, Jessica
    Carlson, Jennifer H.
    Starks, David
    Rojas, Luis
    De, Pradip
    Leyland-Jones, Brian
    MOLECULAR CANCER THERAPEUTICS, 2018, 17 (01)
  • [10] Visualization of cofilin-actin and Ras-Raf interactions by bimolecular fluorescence complementation assays using a new pair of split Venus fragments
    Ohashi, Kazumasa
    Kiuchi, Tai
    Shoji, Kazuyasu
    Sampei, Kaori
    Mizuno, Kensaku
    BIOTECHNIQUES, 2012, 52 (01) : 45 - 50
12345