In Vitro and In Vivo Antidiabetic Effects of Acidic Polysaccharides Extracted from Seaweeds

被引：0

作者：

Moto, Mihoko ^{[1
,2
]}

Murota, Akihiko ^{[3
]}

Takamtzawa, Naoko ^{[4
]}

Nakamura, Asae ^{[1
]}

Iwasaki, Kazuyasu ^{[5
]}

Tanaka, Katsuyuki ^{[5
]}

Katsuraya, Kaname ^{[2
]}

机构：

[1] Wayo Womens Univ, Dept Hlth & Nutr, Ichikawa, Chiba 2728533, Japan

[2] Wayo Womens Univ, Fac Human Ecol, Grad Sch, Ichikawa, Chiba 2728533, Japan

[3] Meiji Univ, Sch Sci & Technol, Tama Ku, Kawasaki, Kanagawa 2148571, Japan

[4] Waseda Univ, Res Org Nano & Life Innovat, Wakamatsu Cho,Shinjuku Ku, Tokyo 1628480, Japan

[5] Okuno Chem Ind Co, Res, Food, Tsurumi Ku, Osaka 5380044, Japan

来源：

JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY | 2023年 / 69卷 / 02期

基金：

日本学术振兴会;

关键词：

seaweeds; acidic polysaccharides; a-glucosidase; optimum molecular-weight range; KK-A(Y )mice; MOLECULAR-WEIGHT POLYSACCHARIDES; STRUCTURAL-CHARACTERIZATION; SULFATED POLYSACCHARIDE; FUCUS-VESICULOSUS; GUT MICROBIOTA; ALPHA-AMYLASE; FUCOIDAN; INHIBITION; GLUCOSE;

D O I：

暂无

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

We evaluated the a-glucosidase inhibitory activity of acidic polysaccharides (APs) extracted from seaweeds in vitro and their antidiabetic effects in KK-A(Y) mice. The a-glucosidase inhibitory activity of APs was differed among various seaweed species. Some APs showed higher inhibitory activity in the high-molecular-weight range, whereas others showed higher inhibitory activity in the low-molecular-weight range. Mice were fed low -mo-lecular-weight APs from hijiki (LMWAPsH), which showed higher a-glucosidase inhibitory activity. Fasting blood glucose and HbA1c levels were significantly lower in the LMWAPsH group than in the control group (p<0.01). The calculated homeostasis model assess-ment-insulin resistance in the LMWAPsH group was significantly lower than that in the control group (p<0.05). These results suggest that a-glucosidase inhibitory activity differ among APs from different seaweed species, and each have an optimum molecular-weight range, and that LMWAPsH prevents the hyperglycemia in ICK-N mice.

引用

页码：98 / 104

页数：7

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