Therapeutic potential of nitric oxide in vascular aging due to the promotion of angiogenesis

被引：7
|
作者：
Zhang, Jiaming [1 ]
Li, Cunrui [1 ]
Zhang, Yihua [1 ]
Wu, Jianbing [1 ]
Huang, Zhangjian [1 ,2 ]
机构：
[1] China Pharmaceut Univ, Ctr Drug Discovery, State Key Lab Nat Med, Jiangsu Key Lab Drug Discovery Metab Dis, Nanjing, Peoples R China
[2] Xinjiang Med Univ, Sch Pharm, Urumqi, Peoples R China
来源：
CHEMICAL BIOLOGY & DRUG DESIGN | 2023年 / 102卷 / 02期
基金：
中国国家自然科学基金;
关键词：
angiogenesis; endothelial cells; nitric oxide; senescence; vascular aging; ENDOTHELIAL PROGENITOR CELLS; SOLUBLE GUANYLYL CYCLASE; OXIDATIVE STRESS; GROWTH-FACTOR; CELLULAR SENESCENCE; VEGF EXPRESSION; DOWN-REGULATION; L-ARGININE; SYNTHASE; ENOS;
D O I：
10.1111/cbdd.14248
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The decrease in angiogenesis that occurs with aging significantly contributes to the higher incidence and mortality of cardiovascular diseases among the elderly. This decline in angiogenesis becomes more pronounced with increasing age and is closely linked to abnormal function and senescence of endothelial cells. Enhancing angiogenesis in aging and targeting senescent endothelial cells have gained considerable attention. Nitric oxide (NO) has been thoroughly investigated for its function in regulating angiogenesis and is an important factor that can counteract endothelial cell senescence. This review summarizes the mechanisms of reduced angiogenesis during aging and therapeutic strategies targeting senescent cells. We also discuss the potential of combining the current approaches with NO in promoting angiogenesis in aging vessels.
引用
收藏
页码：395 / 407
页数：13
相关论文
共 50 条
  • [41] Nitric oxide signaling during myocardial angiogenesis
    Kondo, T
    Kobayashi, K
    Murohara, T
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 2004, 264 (1-2) : 25 - 34
  • [42] Nitric oxide and promotion of cardiac myocyte apoptosis
    Andréka, P
    Tran, T
    Webster, KA
    Bishopric, NH
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 2004, 263 (01) : 35 - 53
  • [43] INDUCIBLE NITRIC OXIDE SYNTHASE MODULATES ANGIOGENESIS IN ISCHEMIC HINDLIMB OF RAT
    Nematollahi, Sedigheh
    Nematbakhsh, Mehdi
    Haghjooyjavanmard, Shaghayegh
    Khazaei, Majid
    Salehi, Mohammad
    BIOMEDICAL PAPERS-OLOMOUC, 2009, 153 (02): : 125 - 129
  • [44] Regulation of retinal angiogenesis by endothelial nitric oxide synthase signaling pathway
    Ha, Jung Min
    Jin, Seo Yeon
    Lee, Hye Sun
    Shin, Hwa Kyoung
    Lee, Dong Hyung
    Song, Sang Heon
    Kim, Chi Dae
    Bae, Sun Sik
    KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2016, 20 (05) : 533 - 538
  • [45] Nitric oxide and promotion of cardiac myocyte apoptosis
    Péter Andréka
    Thanh Tran
    Keith A. Webster
    Nanette H. Bishopric
    Molecular and Cellular Biochemistry, 2004, 263 : 35 - 53
  • [46] Superoxide and nitric oxide in senescence and aging
    Afanas'ev, Igor
    FRONTIERS IN BIOSCIENCE-LANDMARK, 2009, 14 : 3899 - 3912
  • [47] Melatonin Delays Brain Aging by Decreasing the Nitric Oxide Level
    Akbulut, K. G.
    Guney, S.
    Cetin, F.
    Akgun, H. N.
    Aktas, S. H.
    Akbulut, H.
    NEUROPHYSIOLOGY, 2013, 45 (03) : 187 - 192
  • [48] Atherosclerosis, Vascular Aging and Therapeutic Strategies
    Liu Yue
    Chen Ke-ji
    CHINESE JOURNAL OF INTEGRATIVE MEDICINE, 2012, 18 (02) : 83 - 87
  • [49] Angiogenesis revisited - role and therapeutic potential of targeting endothelial metabolism
    Stapor, Peter
    Wang, Xingwu
    Goveia, Jermaine
    Moens, Stijn
    Carmeliet, Peter
    JOURNAL OF CELL SCIENCE, 2014, 127 (20) : 4331 - 4341
  • [50] The telomerase tale in vascular aging: regulation by estrogens and nitric oxide signaling
    Farsetti, Antonella
    Grasselli, Annalisa
    Bacchetti, Silvia
    Gaetano, Carlo
    Capogrossi, Maurizio C.
    JOURNAL OF APPLIED PHYSIOLOGY, 2009, 106 (01) : 333 - 337
12345