Therapeutic potential of nitric oxide in vascular aging due to the promotion of angiogenesis

被引：7

作者：

Zhang, Jiaming ^{[1
]}

Li, Cunrui ^{[1
]}

Zhang, Yihua ^{[1
]}

Wu, Jianbing ^{[1
]}

Huang, Zhangjian ^{[1
,2
]}

机构：

[1] China Pharmaceut Univ, Ctr Drug Discovery, State Key Lab Nat Med, Jiangsu Key Lab Drug Discovery Metab Dis, Nanjing, Peoples R China

[2] Xinjiang Med Univ, Sch Pharm, Urumqi, Peoples R China

来源：

CHEMICAL BIOLOGY & DRUG DESIGN | 2023年 / 102卷 / 02期

基金：

中国国家自然科学基金;

关键词：

angiogenesis; endothelial cells; nitric oxide; senescence; vascular aging; ENDOTHELIAL PROGENITOR CELLS; SOLUBLE GUANYLYL CYCLASE; OXIDATIVE STRESS; GROWTH-FACTOR; CELLULAR SENESCENCE; VEGF EXPRESSION; DOWN-REGULATION; L-ARGININE; SYNTHASE; ENOS;

D O I：

10.1111/cbdd.14248

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The decrease in angiogenesis that occurs with aging significantly contributes to the higher incidence and mortality of cardiovascular diseases among the elderly. This decline in angiogenesis becomes more pronounced with increasing age and is closely linked to abnormal function and senescence of endothelial cells. Enhancing angiogenesis in aging and targeting senescent endothelial cells have gained considerable attention. Nitric oxide (NO) has been thoroughly investigated for its function in regulating angiogenesis and is an important factor that can counteract endothelial cell senescence. This review summarizes the mechanisms of reduced angiogenesis during aging and therapeutic strategies targeting senescent cells. We also discuss the potential of combining the current approaches with NO in promoting angiogenesis in aging vessels.

引用

页码：395 / 407

页数：13

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