The effect of ginger (Zingiber officinale) supplementation on clinical, biochemical, and anthropometric parameters in patients with multiple sclerosis: a double-blind randomized controlled trial

被引:0
|
作者
Foshati, Sahar [1 ]
Poursadeghfard, Maryam [2 ]
Heidari, Zahra [3 ]
Amani, Reza [1 ]
机构
[1] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Esfahan, Iran
[2] Shiraz Univ Med Sci, Clin Neurol Res Ctr, Shiraz, Iran
[3] Isfahan Univ Med Sci, Sch Hlth, Dept Biostat & Epidemiol, Esfahan, Iran
关键词
NEUROFILAMENT LIGHT-CHAIN; CENTRAL-NERVOUS-SYSTEM; IMPACT-SCALE MSIS-29; 6-SHOGAOL; 6-GINGEROL; EXPRESSION; EXTRACT; METALLOPROTEINASES; METAANALYSIS; INVASION;
D O I
10.1039/d3fo00167a
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Introduction: different lines of evidence have shown that ginger administration may be beneficial for patients with multiple sclerosis (MS). Therefore, we aimed to investigate the effect of ginger supplementation on disability, physical and psychological quality of life (QoL), body mass index (BMI), neurofilament light chain (NfL), interlukin-17 (IL-17), matrix metalloproteinase-9 (MMP-9), and neutrophil to lymphocyte ratio (NLR) in patients with relapsing-remitting MS. Methods: this was a 12 week double-blind parallel randomized placebo-controlled trial with a 3 week run-in period. The treatment (n = 26) and control (n = 26) groups received 500 mg ginger and placebo (corn) supplements 3 times daily, respectively. Disability was evaluated using the Expanded Disability Status Scale (EDSS). QoL was rated using the Multiple Sclerosis Impact Scale (MSIS-29). BMI was calculated by dividing weight by height squared. Serum levels of NfL, IL-17, and MMP-9 were measured using the enzyme-linked immunosorbent assay. NLR was determined using a Sysmex XP-300 (TM) automated hematology analyzer. All outcomes were assessed before and after the intervention and analyzed using the intention-to-treat principle. Results: in comparison with placebo, ginger supplementation caused a significant reduction in the EDSS (-0.54 +/- 0.58 vs. 0.08 +/- 0.23, P < 0.001), the MSIS-29 physical scale (-8.15 +/- 15.75 vs. 4.23 +/- 8.46, P = 0.001), the MSIS-29 psychological scale (-15.71 +/- 19.59 vs. 6.68 +/- 10.41, P < 0.001), NfL (-0.14 +/- 0.97 vs. 0.38 +/- 1.06 ng mL(-1), P = 0.049), IL-17 (-3.34 +/- 4.06 vs. 1.77 +/- 6.51 ng L-1, P = 0.003), and NLR (-0.09 +/- 0.53 vs. 0.53 +/- 1.90, P = 0.038). Nevertheless, the differences in BMI and MMP-9 were not significant between the groups. Conclusion: ginger supplementation may be an effective adjuvant therapy for patients with relapsing-remitting MS.
引用
收藏
页码:3701 / 3711
页数:11
相关论文
共 50 条
  • [21] The Effect of Ginger (Zingiber officinale Rosc.) Consumption in Headache Prophylaxis in Patients with Migraine: A Randomized Placebo-Controlled Clinical Trial
    Helli, Bizhan
    Anjirizadeh, Foroogh
    Mehramiri, Asieh
    Shalilahmadi, Davood
    Latifi, Seyed Mahmoud
    JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS, 2022, 17 (03)
  • [22] Effect of ginger (zingiber officinale) on anthropometric and biochemical markers in patients with type 2 diabetes mellitus: integrative review
    Lacerda, Stephany de Souza
    Rubach, Sarah Ceciliano
    Fanchiotti, Flavia Escapini
    Constant, Patricia Beltrao Lessa
    da Silva, Rosimar Regina
    RBONE-REVISTA BRASILEIRA DE OBESIDADE NUTRICAO E EMAGRECIMENTO, 2022, 16 (105): : 1075 - 1094
  • [23] Effect of calcium supplementation on fracture risk: a double-blind randomized controlled trial
    Bischoff-Ferrari, Heike A.
    Rees, Judy R.
    Grau, Maria V.
    Barry, Elizabeth
    Gui, Jiang
    Baron, John A.
    AMERICAN JOURNAL OF CLINICAL NUTRITION, 2008, 87 (06): : 1945 - 1951
  • [24] Effect of BEMER Magnetic Field Therapy on the Level of Fatigue in Patients with Multiple Sclerosis: A Randomized, Double-Blind Controlled Trial
    Piatkowski, Joachim
    Kern, Simone
    Ziemssen, Tjalf
    JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE, 2009, 15 (05) : 507 - 511
  • [25] Efficacy of Ginger Supplementation in Relieving Persistent Hypothyroid Symptoms in Patients with Controlled Primary Hypothyroidism: A Pilot Randomized, Double-Blind, Placebo-Controlled Clinical Trial
    Ashraf, Hamide
    Heydari, Mojtaba
    Shams, Mesbah
    Zarshenas, Mohammad Mehdi
    Tavakoli, Ali
    Sayadi, Mehrab
    EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2022, 2022
  • [26] A Randomized, Double-Blind, Placebo-Controlled Trial of Duloxetine for the Treatment of Pain in Patients with Multiple Sclerosis
    Vollmer, Timothy L.
    Robinson, Michael J.
    Risser, Richard C.
    Malcolm, Sandra K.
    PAIN PRACTICE, 2014, 14 (08) : 732 - 744
  • [27] A randomized, double-blind, placebo-controlled trial to evaluate the effect of nabiximols oromucosal spray on clinical measures of spasticity in patients with multiple sclerosis
    Bethoux, Francois A.
    Farrell, Rachel
    Checketts, Daniel
    Sahr, Natasha
    Berwaerts, Joris
    Alexander, Jessica K.
    Skobieranda, Franck
    MULTIPLE SCLEROSIS AND RELATED DISORDERS, 2024, 89
  • [28] MAGNESIUM SUPPLEMENTATION DURING PREGNANCY - A DOUBLE-BLIND RANDOMIZED CONTROLLED CLINICAL-TRIAL
    SIBAI, BM
    VILLAR, MA
    BRAY, E
    AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1989, 161 (01) : 115 - 119
  • [29] CHOLECALCIFEROL SUPPLEMENTATION AND INFLAMMATION: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED CLINICAL TRIAL
    Seibert, Eric
    Ulrich, Christof
    Trojanowicz, Bogusz
    Lehmann, Ulrike
    Dierkes, Jutta
    Stangl, Gabriele I.
    Girndt, Matthias
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2015, 30
  • [30] Zinc supplementation in prediabetes: A randomized double-blind placebo-controlled clinical trial
    Ranasinghe, Priyanga
    Wathurapatha, Wasundara S.
    Galappatthy, Priyadarshani
    Katulanda, Prasad
    Jayawardena, Ranil
    Constantine, Godwin R.
    JOURNAL OF DIABETES, 2018, 10 (05) : 386 - 397