Copper-Catalyzed Regio- and Stereoselective Hydrothiolation of Allenamides, Enamides, and Ynamides

被引：2

作者：

Pages, Lucas ^{[1
]}

Bouquin, Maxime ^{[1
]}

Jaroschik, Florian ^{[1
]}

Monnier, Florian ^{[1
]}

Taillefer, Marc ^{[1
]}

机构：

[1] Univ Montpellier, ICGM, CNRS, ENSCM, F-34095 Montpellier, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 02期

关键词：

THIOL-ENE CLICK; THIYL RADICALS; ALLENES; HYDROAMINATION; BENZENETHIOL; CONSTRUCTION; ADDITIONS;

D O I：

10.1021/acs.joc.2c02716

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report a simple protocol for the copper-catalyzed hydrothiolation of N-unsaturated precursors, i.e., allenamides, enamides, and ynamides, under mild conditions. This method proceeds with a low loading of a commercially available Cu(CH3CN)(4)PF6 catalyst and enables the room-temperature transformation of a wide range of aromatic and aliphatic thiols into allylic or vinylic thioethers, 1,3-dithioethers, and thioaminals with good regio- and stereoselectivity.

引用

页码：1168 / 1176

页数：9

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