Soluble dietary fiber and cellulose from Saccharina japonica by-product ameliorate Loperamide-induced constipation via modulating enteric neurotransmitters, short-chain fatty acids and gut microbiota

被引：26

作者：

Cao, Junhan ^{[1
,2
]}

Wang, Kai ^{[1
,2
]}

Li, Nianxu ^{[2
]}

Zhang, Liping ^{[2
]}

Qin, Ling ^{[2
]}

He, Yingying ^{[2
]}

Wang, Jingfeng ^{[1
]}

Qu, Changfeng ^{[2
,3
,4
]}

Miao, Jinlai ^{[2
,3
,4
]}

机构：

[1] Ocean Univ China, Coll Food Sci & Engn, Qingdao 266003, Peoples R China

[2] Minist Nat Resources, Inst Oceanog 1, Key Lab Marine Ecoenvironm Sci & Technol, Qingdao 266061, Peoples R China

[3] Qingdao Pilot Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China

[4] Qingdao Key Lab, Marine Nat Prod R&D Lab, Qingdao 266061, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2023年 / 226卷

关键词：

Saccharina japonica; SDF; IDF; Cellulose; Constipation; SCFAs; Gut microbiota; LAMINARIA-JAPONICA; POLYSACCHARIDE; BUTYRATE; PEPTIDE; LIVER; MICE;

D O I：

10.1016/j.ijbiomac.2022.11.243

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of soluble dietary fiber (SDF) and cellulose (IDF) from Saccharina japonica by-product and their differences in improving constipation were further clarified in the present study. We demonstrated that SDF was mainly made up of D-mannuronic acid and D-mannose while IDF consisted of D-glucose , which is different from other reported dietary fibers of terrestrial plants. In this research, both SDF and IDF improved fecal-related in-dicators, gastrointestinal transit rate and histological morphology in Lop-induced mice. Moreover, they could increase the level of antioxidant enzymes (SOD and GSH-Px), restore the expression of enteric neurotransmitters, and maintain the function of ZO-1, JAM-1 as well as Occludin. Interestingly, SDF and IDF had a significant up -regulated effect on the proportion of Muribaculacea, Prevotellaceaen and Lachnospiraceae, which are critical to preserving intestinal immune homeostasis. Besides, they promoted the biosynthesis of short-chain fatty acids (SCFAs). The overall index showed that SDF is more effective for constipation due to its better water retention capacity. Thus, they can be used as a safe dietary supplement for the treatment of chronic or occasional con-stipation in humans.

引用

页码：1319 / 1331

页数：13

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