Effects of 12 Wk of Omega-3 Fatty Acid Supplementation in Long-Distance Runners

Purpose: This study aimed to investigate the effects of 12 wk of omega-3 fatty acid supplementation during endurance training on omega-3 index (O3I) and indicators of running performance in amateur long-distance runners. Methods: Twenty-six amateur male long-distance runners >= 29 yr old supplemented omega-3 fatty acid capsules (OMEGA group, n = 14; 2234 mg of eicosapentaenoic acid and 916 mg of docosahexaenoic acid daily) or medium-chain triglycerides capsules as placebo (medium-chain triglyceride [MCT] group, n = 12; 4000 mg of MCT daily) during 12 wk of endurance training. Before and after intervention, blood samples were collected for O3I assessment, and an incremental test to exhaustion and a 1500-m run trial were performed. Results: O3I was significantly increased in the OMEGA group (from 5.8% to 11.6%, P < 0.0001). A significant increase in (V) over dotO(2peak) was observed in the OMEGA group (from 53.6 +/- 4.4 to 56.0 +/- 3.7 mL center dot kg(-1)center dot min(-1), P = 0.0219) without such change in MCT group (from 54.7 +/- 6.8 to 56.4 +/- 5.9 mL center dot kg(-1)center dot min(-1), P = 0.1308). A positive correlation between the change in O3I and the change in running economy was observed when data of participants from both groups were combined (-0.1808 +/- 1.917, P = 0.0020), without such an effect in OMEGA group alone (P = 0.1741). No effect of omega-3 supplementation on 1500-m run results was observed. Conclusions: Twelve weeks of omega-3 fatty acid supplementation at a dose of 2234 mg of eicosapentaenoic acid and 916 mg of docosahexaenoic acid daily during endurance training resulted in the improvement of O3I and running economy and increased (V) over dotO(2peak) without improvement in the 1500-m run trial time in amateur runners.