Risk of COVID-19 Hospitalization and Protection Associated With mRNA Vaccination Among US Adults With Psychiatric Disorders

被引：0

作者：

Levy, Matthew E. ^{[1
,2
]}

Yang, Duck-Hye ^{[1
]}

Dunne, Margaret M. ^{[1
]}

Miley, Kathleen ^{[3
]}

Irving, Stephanie A. ^{[4
]}

Grannis, Shaun J. ^{[5
,6
]}

Weber, Zachary A. ^{[1
]}

Griggs, Eric P. ^{[7
]}

Spark, Talia L. ^{[1
]}

Bassett, Elizabeth ^{[1
]}

Embi, Peter J. ^{[5
,8
]}

Gaglani, Manjusha ^{[9
,10
]}

Natarajan, Karthik ^{[11
,12
]}

Valvi, Nimish R. ^{[5
]}

Ong, Toan C. ^{[13
]}

Naleway, Allison L. ^{[4
]}

Stenehjem, Edward ^{[14
]}

Klein, Nicola P. ^{[15
]}

Link-Gelles, Ruth ^{[7
]}

Desilva, Malini B. ^{[3
]}

Kharbanda, Anupam B. ^{[16
]}

Raiyani, Chandni ^{[9
]}

Beaton, Maura A. ^{[11
]}

Dixon, Brian E. ^{[5
,17
]}

Rao, Suchitra ^{[13
]}

Dascomb, Kristin ^{[14
]}

Patel, Palak ^{[18
]}

Mamawala, Mufaddal ^{[9
]}

Han, Jungmi ^{[11
]}

Fadel, William F. ^{[5
,17
]}

Barron, Michelle A. ^{[13
]}

Grisel, Nancy ^{[14
]}

Dickerson, Monica ^{[18
]}

Liao, I-Chia ^{[9
]}

Arndorfer, Julie ^{[14
]}

Najdowski, Morgan ^{[7
]}

Murthy, Kempapura ^{[9
]}

Ray, Caitlin ^{[18
]}

Tenforde, Mark W. ^{[18
]}

Ball, Sarah W. ^{[1
]}

机构：

[1] Westat Corp, Rockville, MD 20850 USA

[2] Helix, San Mateo, CA 94401 USA

[3] HealthPartners Inst, Minneapolis, MN USA

[4] Kaiser Permanente Ctr Hlth Res, Portland, OR USA

[5] Regenstrief Inst Hlth Care, Ctr Biomed Informat, Indianapolis, IN USA

[6] Indiana Univ, Sch Med, Indianapolis, IN USA

[7] Ctr Dis Control & Prevent, Coronavirus & Other Resp Viruses Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA

[8] Vanderbilt Univ, Med Ctr, Nashville, TN USA

[9] Baylor Scott & White Hlth, Temple, TX USA

[10] Texas A&M Univ, Coll Med, Temple, TX USA

[11] Columbia Univ, Irving Med Ctr, Dept Biomed Informat, New York, NY USA

[12] New York Presbyterian Hosp, New York, NY USA

[13] Univ Colorado, Sch Med, Anschutz Med Campus, Aurora, CO USA

[14] Intermt Healthcare, Div Infect Dis & Clin Epidemiol, Salt Lake City, UT USA

[15] Kaiser Permanente Northern Calif Div Res, Kaiser Permanente Vaccine Study Ctr, Oakland, CA USA

[16] Childrens Minnesota, Minneapolis, MN USA

[17] Indiana Univ, Fairbanks Sch Publ Hlth, Indianapolis, IN USA

[18] Ctr Dis Control & Prevent, Influenza Div, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA

来源：

INFLUENZA AND OTHER RESPIRATORY VIRUSES | 2024年 / 18卷 / 03期

关键词：

anxiety disorders; COVID-19; electronic health records; epidemiology; mental disorders; mood disorders; psychotic disorders; vaccination; TEST-NEGATIVE DESIGN; CARE;

D O I：

10.1111/irv.13269

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Background: Although psychiatric disorders have been associated with reduced immune responses to other vaccines, it remains unknown whether they influence COVID-19 vaccine effectiveness (VE). This study evaluated risk of COVID-19 hospitalization and estimated mRNA VE stratified by psychiatric disorder status. Methods: In a retrospective cohort analysis of the VISION Network in four US states, the rate of laboratory-confirmed COVID-19-associated hospitalization between December 2021 and August 2022 was compared across psychiatric diagnoses and by monovalent mRNA COVID-19 vaccination status using Cox proportional hazards regression. Results: Among 2,436,999 adults, 22.1% had >= 1 psychiatric disorder. The incidence of COVID-19-associated hospitalization was higher among patients with any versus no psychiatric disorder (394 vs. 156 per 100,000 person-years, p < 0.001). Any psychiatric disorder (adjusted hazard ratio [aHR], 1.27; 95% CI, 1.18-1.37) and mood (aHR, 1.25; 95% CI, 1.15-1.36), anxiety (aHR, 1.33, 95% CI, 1.22-1.45), and psychotic (aHR, 1.41; 95% CI, 1.14-1.74) disorders were each significant independent predictors of hospitalization. Among patients with any psychiatric disorder, aHRs for the association between vaccination and hospitalization were 0.35 (95% CI, 0.25-0.49) after a recent second dose, 0.08 (95% CI, 0.06-0.11) after a recent third dose, and 0.33 (95% CI, 0.17-0.66) after a recent fourth dose, compared to unvaccinated patients. Corresponding VE estimates were 65%, 92%, and 67%, respectively, and were similar among patients with no psychiatric disorder (68%, 92%, and 79%). Conclusion: Psychiatric disorders were associated with increased risk of COVID-19-associated hospitalization. However, mRNA vaccination provided similar protection regardless of psychiatric disorder status, highlighting its benefit for individuals with psychiatric disorders.

引用

页数：13

共 32 条

[1] The Impact of Substance Use Disorder on COVID-19 Outcomes [J].

Baillargeon, Jacques ;

Polychronopoulou, Efstathaia ;

Kuo, Yong-Fang ;

Raji, Mukaila A. .

PSYCHIATRIC SERVICES, 2021, 72 (05) :578-581

[2]

Britton A, 2022, MMWR-MORBID MORTAL W, V71, P1335, DOI 10.15585/mmwr.mm7142a4

[3]

Centers for Disease Control and Prevention, 2023, Underlying Medical Conditions Associated With Higher Risk for Severe COVID-19: Information for Healthcare Professionals

[4] Risk factors for poor COVID-19 outcomes in patients with psychiatric disorders [J].

Cheng, Wan-Ju ;

Shih, Hong-Mo ;

Su, Kuan-Pin ;

Hsueh, Po-Ren .

BRAIN BEHAVIOR AND IMMUNITY, 2023, 114 :255-261

[5]

De Hert M, 2011, WORLD PSYCHIATRY, V10, P138

[6] The Effect of Smoking on Humoral Response to COVID-19 Vaccines: A Systematic Review of Epidemiological Studies [J].

Ferrara, Pietro ;

Gianfredi, Vincenza ;

Tomaselli, Venera ;

Polosa, Riccardo .

VACCINES, 2022, 10 (02)

[7] Association Between Mental Health Disorders and Mortality Among Patients With COVID-19 in 7 Countries A Systematic Review and Meta-analysis [J].

Fond, Guillaume ;

Nemani, Katlyn ;

Etchecopar-Etchart, Damien ;

Loundou, Anderson ;

Goff, Donald C. ;

Lee, Seung Won ;

Lancon, Christophe ;

Auquier, Pascal ;

Baumstarck, Karine ;

Llorca, Pierre-Michel ;

Yon, Dong Keon ;

Boyer, Laurent .

JAMA PSYCHIATRY, 2021, 78 (11) :1208-1217

[8] The case test-negative design for studies of the effectiveness of influenza vaccine [J].

Foppa, Ivo M. ;

Haber, Michael ;

Ferdinands, Jill M. ;

Shay, David K. .

VACCINE, 2013, 31 (30) :3104-3109

[9] Basic principles of test-negative design in evaluating influenza vaccine effectiveness [J].

Fukushima, Wakaba ;

Hirota, Yoshio .

VACCINE, 2017, 35 (36) :4796-4800

[10] Vaccine effectiveness of BNT162b2 and CoronaVac against SARS-CoV-2 omicron infection and related hospital admission among people with substance use disorder in Hong Kong: a matched case-control study [J].

Huang, Caige ;

Wei, Yue ;

Yan, Vincent K. C. ;

Ye, Xuxiao ;

Kang, Wei ;

Yiu, Hei Hang Edmund ;

Shami, Jessica J. P. ;

Cowling, Benjamin J. ;

Tse, Man Li ;

Castle, David J. ;

Chui, Celine S. L. ;

Lai, Francisco T. T. ;

Li, Xue ;

Wan, Eric Y. F. ;

Wong, Carlos K. H. ;

Hayes, Joseph F. ;

Chang, Wing Chung ;

Chung, Albert K. K. ;

Lau, Chak Sing ;

Wong, Ian C. K. ;

Chan, Esther W. .

LANCET PSYCHIATRY, 2023, 10 (06) :403-413

← 1 2 3 4 →