Alcohol and the risk of all-cause death, atrial fibrillation, ventricular arrhythmia, and sudden cardiac arrest

被引：2

作者：

Kim, Yun Gi ^{[1
,2
]}

Kim, Dong Yun ^{[3
]}

Roh, Seung-Young ^{[4
,5
]}

Jeong, Joo Hee ^{[1
,2
]}

Lee, Hyoung Seok ^{[1
,2
]}

Min, Kyongjin ^{[1
,2
]}

Choi, Yun Young ^{[1
,2
]}

Han, Kyung-Do ^{[2
,6
]}

Shim, Jaemin ^{[1
,2
]}

Choi, Jong-Il ^{[1
,2
]}

Kim, Young-Hoon ^{[1
,2
]}

机构：

[1] Korea Univ, Dept Internal Med, Div Cardiol, Div Cardiol,Coll Med, 73 Goryeodae Ro, Seoul 02841, South Korea

[2] Korea Univ Anam Hosp, 73 Goryeodae Ro, Seoul 02841, South Korea

[3] Korea Univ, Coll Med, Seoul, South Korea

[4] Korea Univ, Dept Internal Med, Div Cardiol, Div Endocrinol & Metab,Coll Med, Seoul, South Korea

[5] Korea Univ, Guro Hosp, Seoul, South Korea

[6] Soongsil Univ, Dept Stat & Actuarial Sci, Seoul, South Korea

来源：

SCIENTIFIC REPORTS | 2024年 / 14卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Sudden cardiac arrest; Atrial fibrillation; Ventricular arrhythmia; Alcohol; GENE-EXPRESSION; T-PA; CONSUMPTION; DISEASE;

D O I：

10.1038/s41598-024-55434-6

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The risk of having atrial fibrillation (AF) is associated with alcohol intake. However, it is not clear whether sudden cardiac arrest (SCA) and ventricular arrhythmia (VA) including ventricular tachycardia, flutter, or fibrillation have similar associations with alcohol. We aimed to evaluate the association of alcohol intake with all-cause death, new-onset AF, VA, and SCA using single cohort with a sufficient sample size. A total of 3,990,373 people without a prior history of AF, VAs, or SCA was enrolled in this study based on nationwide health check-up in 2009. We classified the participants into four groups according to weekly alcohol consumption, and evaluated the association of alcohol consumption with each outcome. We observed a significant association between mild (hazard ratio [HR] = 0.826; 95% confidence interval [CI] = 0.815-0.838) to moderate (HR = 0.930; 95% CI = 0.912-0.947) drinking with decreased risk of all-cause mortality. However heavy drinking (HR = 1.108; 95% CI = 1.087-1.129) was associated with increased all-cause death. The risk of new-onset AF was significantly associated with moderate (HR = 1.129; 95% CI = 1.097-1.161) and heavy (HR = 1.298; 95% CI = 1.261-1.337) drinking. However, the risk of SCA showed negative association with all degrees of alcohol intake: 20% (HR = 0.803; 95% CI = 0.769-0.839), 15% (HR = 0.853; 95% CI = 0.806-0.902), and 8% (HR = 0.918; 95% CI = 0.866-0.974) lower risk for mild, moderate, and heavy drinkers, respectively. Mild drinking was associated with reduced risk of VA with moderate and heavy drinking having no associations. In conclusion, the association between alcohol and various outcomes in this study were heterogeneous. Alcohol might have different influences on various cardiac disorders.

引用

页数：10