Hydrodifluoromethylation of unactivated alkenes enabled by Visible-Light Photocatalysis

In the present manuscript, we have reported a general catalytic strategy that allows the synthesis of a variety of difluoro methylated alkanes from the corresponding unactivated alkenes using commercially available radical difluoromethylating reagent (CF2HSO2Na) under visible light photocatalysis. Further, this strategy allows the late-stage modification of various alkenes derived from pharmaceutically relevant drugs. Photocatalytic hydro-difluoromethylaton of unactivated alkenes has been developed using a commercially available difluoromethylating reagent (CF2HSO2Na). This methodology tolerates a variety of functional groups and allows late-stage modification of various alkenes derived from pharmaceutically relevant drugs. image