Impact of Respiratory Viral Infections in Transplant Recipients

被引：1

作者：

Bahakel, Hannah ^{[1
]}

Waghmare, Alpana ^{[2
,3
]}

Madan, Rebecca Pellet ^{[4
,5
]}

机构：

[1] Cincinnati Childrens Hosp Med Ctr, Div Infect Dis, Cincinnati, OH 45229 USA

[2] Univ Washington, Fred Hutchinson Canc Res Ctr, Dept Pediat, Seattle, WA USA

[3] Seattle Childrens Hosp, Dept Infect Dis, Seattle, WA USA

[4] NYU, Grossman Sch Med, New York, NY USA

[5] Hassenfeld Childrens Hosp, Dept Infect Dis, New York, NY USA

来源：

JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY | 2024年 / 13卷

关键词：

hematopoietic transplantation; solid organ transplantation; viral respiratory infection; STEM-CELL TRANSPLANT; SOLID-ORGAN TRANSPLANT; SYNCYTIAL VIRUS-INFECTIONS; DISSEMINATED ADENOVIRUS INFECTION; PANDEMIC INFLUENZA A/H1N1; LIVER-TRANSPLANT; PALIVIZUMAB PROPHYLAXIS; SEASONAL INFLUENZA; RSV INFECTION; CHILDREN;

D O I：

10.1093/jpids/piad094

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Respiratory viral infections (RVIs) are among the leading cause of morbidity and mortality in pediatric hematopoietic stem cell transplant (HCT) and solid organ transplant (SOT) recipients. Transplant recipients remain at high risk for super imposed bacterial and fungal pneumonia, chronic graft dysfunction, and graft failure as a result of RVIs. Recent multicenter retrospective studies and prospective studies utilizing contemporary molecular diagnostic techniques have better delineated the epidemiology and outcomes of RVIs in pediatric transplant recipients and have advanced the development of preventative vaccines and treatment interventions in this population. In this review, we will define the epidemiology and outcomes of RVIs in SOT and HSCT recipients, describe the available assays for diagnosing a suspected RVI, highlight evolving management and vaccination strategies, review the risk of donor derived RVI in SOT recipients, and discuss considerations for delaying transplantation in the presence of an RVI.

引用

页码：S39 / S48

页数：10

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