Comparison of plasma proteomic profiles of patients with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis and infectious mononucleosis

被引：7

作者：

Haruta, Kazunori ^{[1
]}

Suzuki, Takako ^{[1
]}

Yamaguchi, Makoto ^{[1
]}

Fukuda, Yuto ^{[1
]}

Torii, Yuka ^{[1
]}

Takahashi, Yoshiyuki ^{[1
]}

Ito, Yoshinori ^{[2
]}

Kawada, Jun-ichi ^{[1
,3
]}

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Pediat, Nagoya, Japan

[2] Aichi Med Univ, Dept Pediat, Nagakute, Japan

[3] Nagoya Univ, Grad Sch Med, Dept Pediat, 65 Tsurumai Cho,Showa Ku, Nagoya 4668550, Japan

来源：

JOURNAL OF MEDICAL VIROLOGY | 2024年 / 96卷 / 02期

基金：

日本学术振兴会;

关键词：

apolipoprotein E; Epstein-Barr Virus; hemophagocytic lymphohistiocytosis; infectious mononucleosis; liquid chromatography-mass spectrometry; proteomic profile; APOLIPOPROTEIN-E;

D O I：

10.1002/jmv.29450

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Primary Epstein-Barr virus (EBV) infection occasionally causes EBV-infectious mononucleosis (EBV-IM) and EBV-hemophagocytic lymphohistiocytosis (EBV-HLH). Although EBV-IM is mostly mild and self-limiting, EBV-HLH is a life-threatening disease characterized by excessive immune activation. However, the pathogenesis of EBV-HLH is yet to be fully elucidated. A diagnostic biomarker for EBV-HLH is desirable because early diagnosis and treatment are critical for the effective management of patients. In this study, the proteomic profiling of plasma was performed using liquid chromatography-mass spectrometry to identify proteins specific to EBV-IM and EBV-HLH. Furthermore, pathway analysis was performed for the proteins upregulated in patients with EBV-IM and EBV-HLH. Compared to healthy controls, 63 and 18 proteins were upregulated in patients with EBV-IM and EBV-HLH, respectively. Pathway and process enrichment analyses revealed that the complement system was the most enriched category of upregulated proteins in EBV-IM, whereas proteins related to immune effector processes were the most enriched in EBV-HLH. Among the 18 proteins upregulated in EBV-HLH, seven were exclusive to EBV-HLH. These specific proteins were associated with three pathways, and apolipoprotein E was commonly found in all the pathways. Proteomic analysis may provide new insights into the host response to EBV infection and the pathogenesis of EBV-related diseases.

引用

页数：8

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