Potential Therapeutic Effects of Short-Chain Fatty Acids on Chronic Pain

被引：7
作者：
Tang, Yuanyuan [1 ,2 ]
Du, Juan [1 ]
Wu, Hongfeng [1 ]
Wang, Mengyao [1 ]
Liu, Sufang [3 ]
Tao, Feng [3 ]
机构：
[1] Xinxiang Med Univ, Sch Basic Med Sci, Xinxiang, Henan, Peoples R China
[2] Key Lab Mol Neurol Xinxiang, Xinxiang, Henan, Peoples R China
[3] Texas A&M Univ, Dept Biomed Sci, Coll Dent, Dallas, TX 75231 USA
来源：
CURRENT NEUROPHARMACOLOGY | 2024年 / 22卷 / 02期
关键词：
Short-chain fatty acids; chronic pain; gut microbiome; metabolites; gut-brain communication; intestinal diseases; GLUCAGON-LIKE PEPTIDE-1; PROTEIN-COUPLED RECEPTOR; PROLIFERATOR-ACTIVATED RECEPTOR; CHRONIC CONSTRICTION INJURY; IRRITABLE-BOWEL-SYNDROME; SODIUM-BUTYRATE; GUT MICROBIOTA; NEUROPATHIC PAIN; MONOCARBOXYLATE TRANSPORTERS; VISCERAL HYPERSENSITIVITY;
D O I：
10.2174/1570159X20666220927092016
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The intestinal homeostasis maintained by the gut microbiome and relevant metabolites is essential for health, and its disturbance leads to various intestinal or extraintestinal diseases. Recent studies suggest that gut microbiome-derived metabolites short-chain fatty acids (SCFAs) are involved in different neurological disorders (such as chronic pain). SCFAs are produced by bacterial fermentation of dietary fibers in the gut and contribute to multiple host processes, including gastrointestinal regulation, cardiovascular modulation, and neuroendocrine-immune homeostasis. Although SCFAs have been implicated in the modulation of chronic pain, the detailed mechanisms that underlie such roles of SCFAs remain to be further investigated. In this review, we summarize currently available research data regarding SCFAs as a potential therapeutic target for chronic pain treatment and discuss several possible mechanisms by which SCFAs modulate chronic pain.
引用
收藏
页码：191 / 203
页数：13
相关论文
共 165 条
  • [1] Short-Chain Fatty Acids Stimulate Angiopoietin-Like 4 Synthesis in Human Colon Adenocarcinoma Cells by Activating Peroxisome Proliferator-Activated Receptor γ
    Alex, Sheril
    Lange, Katja
    Amolo, Tom
    Grinstead, Jeffrey S.
    Haakonsson, Anders K.
    Szalowska, Ewa
    Koppen, Arjen
    Mudde, Karin
    Haenen, Danielle
    Al-Lahham, Sa'ad
    Roelofsen, Han
    Houtman, Rene
    van der Burg, Bart
    Mandrup, Susanne
    Bonvin, Alexandre M. J. J.
    Kalkhoven, Eric
    Muller, Michael
    Hooiveld, Guido J.
    Kersten, Sander
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2013, 33 (07) : 1303 - 1316
  • [2] Human brain mechanisms of pain perception and regulation in health and disease
    Apkarian, AV
    Bushnell, MC
    Treede, RD
    Zubieta, JK
    [J]. EUROPEAN JOURNAL OF PAIN, 2005, 9 (04) : 463 - 484
  • [3] SHORT CHAIN FATTY-ACIDS IN PLASMA AND BRAIN - QUANTITATIVE-DETERMINATION BY GAS-CHROMATOGRAPHY
    BACHMANN, C
    COLOMBO, JP
    BERUTER, J
    [J]. CLINICA CHIMICA ACTA, 1979, 92 (02) : 153 - 159
  • [4] Memory CD8+ T Cells Balance Pro- and Anti-inflammatory Activity by Reprogramming Cellular Acetate Handling at Sites of Infection
    Balmer, Maria L.
    Ma, Eric H.
    Thompson, Andrew J.
    Epple, Raja
    Unterstab, Gunhild
    Loetscher, Jonas
    Dehio, Philippe
    Schuerch, Christian M.
    Warncke, Jan D.
    Perrin, Gaelle
    Woischnig, Anne-Kathrin
    Graehlert, Jasmin
    Loeliger, Jordan
    Assmann, Nadine
    Bantug, Glenn R.
    Schaeren, Olivier P.
    Khanna, Nina
    Egli, Adrian
    Bubendorf, Lukas
    Rentsch, Katharina
    Hapfelmeier, Siegfried
    Jones, Russell G.
    Hess, Christoph
    [J]. CELL METABOLISM, 2020, 32 (03) : 457 - +
  • [5] Microencapsulated sodium butyrate reduces the frequency of abdominal pain in patients with irritable bowel syndrome
    Banasiewicz, T.
    Krokowicz, L.
    Stojcev, Z.
    Kaczmarek, B. F.
    Kaczmarek, E.
    Maik, J.
    Marciniak, R.
    Krokowicz, P.
    Walkowiak, J.
    Drews, M.
    [J]. COLORECTAL DISEASE, 2013, 15 (02) : 204 - 209
  • [6] Sodium Butyrate Prevents Memory Impairment by Re-establishing BDNF and GDNF Expression in Experimental Pneumococcal Meningitis
    Barichello, Tatiana
    Generoso, Jaqueline S.
    Simoes, Lutiana R.
    Faller, Cristiano Julio
    Ceretta, Renan A.
    Petronilho, Fabricia
    Lopes-Borges, Jessica
    Valvassori, Samira S.
    Quevedo, Joao
    [J]. MOLECULAR NEUROBIOLOGY, 2015, 52 (01) : 734 - 740
  • [7] GHB (γ-hydroxybutyrate) carrier-mediated transport across the blood-brain barrier
    Bhattacharya, I
    Boje, KMK
    [J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2004, 311 (01) : 92 - 98
  • [8] Vagal tone: effects on sensitivity, motility, and inflammation
    Bonaz, B.
    Sinniger, V.
    Pellissier, S.
    [J]. NEUROGASTROENTEROLOGY AND MOTILITY, 2016, 28 (04) : 455 - 462
  • [9] The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis
    Bonaz, Bruno
    Bazin, Thomas
    Pellissier, Sonia
    [J]. FRONTIERS IN NEUROSCIENCE, 2018, 12
  • [10] Molecular cloning and tissue expression of a novel orphan G protein-coupled receptor from rat lung
    Bonini, JA
    Anderson, SM
    Steiner, DF
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 234 (01) : 190 - 193
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