Quantitative PCR-Based Diagnosis and Follow-up of Chagas Disease Primary Infection After Solid Organ Transplant: A Multicentre Study

被引：8

作者：

Barcan, Laura A. ^{[1
]}

Smud, Astrid ^{[1
]}

Besuschio, Susana A. ^{[2
]}

Giorgio, Patricia L. ^{[3
]}

Temporiti, Elena ^{[4
]}

Salgueira, Claudia ^{[5
]}

Pinoni, Maria V. ^{[3
]}

Nagel, Claudia ^{[6
]}

Schijman, Alejandro G. ^{[2
]}

机构：

[1] Hosp Italiano Buenos Aires, Dept Med, Secc Infectol, Buenos Aires, DF, Argentina

[2] Consejo Nacl Ciencia & Technol, Inst Invest Ingn Genet & Biol Mol, Lab Biol Mol Enfermedad Chagas, Buenos Aires, DF, Argentina

[3] Hosp Britanico Buenos Aires, Serv Infectol, Buenos Aires, DF, Argentina

[4] Ctr Educ Med & Invest Clin, Dept Med, Secc Infectol, Buenos Aires, DF, Argentina

[5] Sanatorios Trinidad Mitre & Anchorena, Buenos Aires, DF, Argentina

[6] Hosp Univ Fdn Favaloro, Buenos Aires, DF, Argentina

来源：

JOURNAL OF INFECTIOUS DISEASES | 2023年 / 228卷 / 09期

关键词：

Chagas disease; immunosupression; polymerase chain reaction; primary infection; solid organ transplantation; TRYPANOSOMA-CRUZI INFECTION; LIVER-TRANSPLANTATION; REACTIVATION; DONORS;

D O I：

10.1093/infdis/jiad289

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chagas disease in solid organ transplant recipients may present as a primary infection (PI). Early detection is crucial for timely treatment. This is the largest observational multicentre study evaluating qPCR for early diagnosis and treatment monitoring of PI in seronegative recipients of organs from seropositive donors. Of 34 patients admitted at 5 health centers, PI was detected by qPCR in 8 (23.5%) within a posttransplant period of 40 days (interquartile range [IQR], 31-50 days). No PI was detected by the Strout test or clinical symptoms/signs. All patients had favorable treatment outcome with negative qPCR 31 days (IQR, 18-35 days) after treatment, with no posttreatment relapse episodes.

引用

页码：1304 / 1308

页数：5

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