Strategies to improve γδTCRs engineered T-cell therapies for the treatment of solid malignancies

被引：1
作者：
Meringa, A. D. [1 ]
Hernandez-Lopez, P. [1 ]
Cleven, A. [1 ]
de Witte, M. [1 ,2 ]
Straetemans, T. [1 ,2 ]
Kuball, J. [1 ,2 ]
Beringer, D. X. [1 ]
Sebestyen, Z. [1 ]
机构：
[1] Univ Utrecht, Univ Med Ctr Utrecht, Ctr Translat Immunol, Utrecht, Netherlands
[2] Univ Utrecht, Univ Med Ctr Utrecht, Dept Hematol, Utrecht, Netherlands
来源：
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
关键词：
T-cell therapy; gamma delta TCR; cancer; immune therapy; antigen; fitness; TME (tumor microenvironment); migration; ANTIGEN RECEPTOR; ANTITUMOR-ACTIVITY; 4-1BB COSTIMULATION; RECOGNITION; LYMPHOCYTES; TUMORS; STRESS; MICROENVIRONMENT; IMMUNOTHERAPY; CYTOKINE;
D O I：
10.3389/fimmu.2023.1159337
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
引用
收藏
页数：7
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共 96 条
  • [1] Four challenges to CAR T cells breaking the glass ceiling
    Bailey, Stefanie R.
    Berger, Trisha R.
    Graham, Charlotte
    Larson, Rebecca C.
    Maus, Marcela V.
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2023,
  • [2] Cellular immunotherapy on primary multiple myeloma expanded in a 3D bone marrow niche model
    Braham, Maaike V. J.
    Minnema, Monique C.
    Aarts, Tineke
    Sebestyen, Zsolt
    Straetemans, Trudy
    Vyborova, Anna
    Kuball, Jurgen
    Oner, F. Cumhur
    Robin, Catherine
    Alblas, Jacqueline
    [J]. ONCOIMMUNOLOGY, 2018, 7 (06):
  • [3] CD1: Antigen presentation and T cell function
    Brigl, M
    Brenner, MB
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, 2004, 22 : 817 - 890
  • [4] Calderon H, 2020, METHODS MOL BIOL, V2086, P223, DOI 10.1007/978-1-0716-0146-4_17
  • [5] Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes
    Caruana, Ignazio
    Savoldo, Barbara
    Hoyos, Valentina
    Weber, Gerrit
    Liu, Hao
    Kim, Eugene S.
    Ittmann, Michael M.
    Marchetti, Dario
    Dotti, Gianpietro
    [J]. NATURE MEDICINE, 2015, 21 (05) : 524 - U158
  • [6] Diversity in recognition and function of human γδ T cells
    Castro, Caitlin D.
    Boughter, Christopher T.
    Broughton, Augusta E.
    Ramesh, Amrita
    Adams, Erin J.
    [J]. IMMUNOLOGICAL REVIEWS, 2020, 298 (01) : 134 - 152
  • [7] NKG2A expression identifies a subset of human Vδ2 T cells exerting the highest antitumor effector functions
    Cazzetta, Valentina
    Bruni, Elena
    Terzoli, Sara
    Carenza, Claudia
    Franzese, Sara
    Piazza, Rocco
    Marzano, Paolo
    Donadon, Matteo
    Torzilli, Guido
    Cimino, Matteo
    Simonelli, Matteo
    Bello, Lorenzo
    Villa, Anna
    Tan, Likai
    Ravens, Sarina
    Prinz, Immo
    Supino, Domenico
    Colombo, Federico S.
    Lugli, Enrico
    Marcenaro, Emanuela
    Vivier, Eric
    Della Bella, Silvia
    Mikulak, Joanna
    Mavilio, Domenico
    [J]. CELL REPORTS, 2021, 37 (03):
  • [8] Construction of PD1/CD28 chimeric-switch receptor enhances anti-tumor ability of c-Met CAR-T in gastric cancer
    Chen, Cong
    Gu, Yan-Mei
    Zhang, Fan
    Zhang, Zheng-Chao
    Zhang, Ya-Ting
    He, Yi-Di
    Wang, Ling
    Zhou, Ning
    Tang, Fu-Tian
    Liu, Hong-Jian
    Li, Yu-Min
    [J]. ONCOIMMUNOLOGY, 2021, 10 (01):
  • [9] CAR T Cells Releasing IL-18 Convert to T-Bethigh FoxO1low Effectors that Exhibit Augmented Activity against Advanced Solid Tumors
    Chmielewski, Markus
    Abken, Hinrich
    [J]. CELL REPORTS, 2017, 21 (11): : 3205 - 3219
  • [10] Of CARs and TRUCKs: chimeric antigen receptor (CAR) T cells engineered with an inducible cytokine to modulate the tumor stroma
    Chmielewski, Markus
    Hombach, Andreas A.
    Abken, Hinrich
    [J]. IMMUNOLOGICAL REVIEWS, 2014, 257 (01) : 83 - 90
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