Targeted Protein Degradation Technology and Nanomedicine: Powerful Allies against Cancer

被引：16
作者：
Lin, Jia-Yi [1 ]
Liu, Hai-Jun [2 ,3 ]
Wu, Ye [1 ]
Jin, Jin-Mei [1 ]
Zhou, Yu-Dong [4 ]
Zhang, Hong [1 ]
Nagle, Dale G. [5 ,6 ]
Chen, Hong-Zhuan [1 ]
Zhang, Wei-Dong [1 ]
Luan, Xin [1 ]
机构：
[1] Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Integrat Med Res, Shanghai Frontiers Sci Ctr TCM Chem Biol, Shanghai 201203, Peoples R China
[2] Harvard Med Sch, Brigham & Womens Hosp, Ctr Nanomed, Boston, MA 02115 USA
[3] Harvard Med Sch, Brigham & Womens Hosp, Dept Anesthesiol, Boston, MA 02115 USA
[4] Univ Mississippi, Coll Liberal Arts, Dept Chem & Biochem, Univ 1848, Boston, MA USA
[5] Univ Mississippi, Sch Pharm, Dept BioMol Sci, Univ 1848, Boston, MA USA
[6] Univ Mississippi, Res Inst Pharmaceut Sci, Sch Pharm, Univ 1848, Boston, MA USA
来源：
SMALL | 2023年 / 19卷 / 18期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
cancer; drug delivery; nanomedicine; targeted protein degradation; IN-VIVO; AUTOPHAGY; LENALIDOMIDE; DELIVERY; UBIQUITINATION; NANOPARTICLES; KNOCKDOWN; PROTACS; GOLD; THERANOSTICS;
D O I：
10.1002/smll.202207778
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Targeted protein degradation (TPD) is an emerging therapeutic strategy with the potential of targeting undruggable pathogenic proteins. After the first proof-of-concept proteolysis-targeting chimeric (PROTAC) molecule was reported, the TPD field has entered a new era. In addition to PROTAC, numerous novel TPD strategies have emerged to expand the degradation landscape. However, their physicochemical properties and uncontrolled off-target side effects have limited their therapeutic efficacy, raising concerns regarding TPD delivery system. The combination of TPD and nanotechnology offers great promise in improving safety and therapeutic efficacy. This review provides an overview of novel TPD technologies, discusses their clinical applications, and highlights the trends and perspectives in TPD nanomedicine.
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页数：14
相关论文
共 111 条
  • [1] LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation
    Ahn, Green
    Banik, Steven M.
    Miller, Caitlyn L.
    Riley, Nicholas M.
    Cochran, Jennifer R.
    Bertozzi, Carolyn R.
    [J]. NATURE CHEMICAL BIOLOGY, 2021, 17 (09) : 937 - 946
  • [2] [Anonymous], 2020, Cancer Discov, V10, P1084, DOI 10.1158/2159-8290.CD-NB2020-054
  • [3] Lysosome-targeting chimaeras for degradation of extracellular proteins
    Banik, Steven M.
    Pedram, Kayvon
    Wisnovsky, Simon
    Ahn, Green
    Riley, Nicholas M.
    Bertozzi, Carolyn R.
    [J]. NATURE, 2020, 584 (7820) : 291 - +
  • [4] Awakening p53 in vivo by D-peptides-functionalized ultra-small nanoparticles: Overcoming biological barriers to D-peptide drug delivery
    Bian, Zhenyuan
    Yan, Jin
    Wang, Simeng
    Li, Yijie
    Guo, Yi
    Ma, Bohan
    Guo, Hao
    Lei, Zhijie
    Yin, Chun
    Zhou, Yi
    Liu, Min
    Tao, Kaishan
    Hou, Peng
    He, Wangxiao
    [J]. THERANOSTICS, 2018, 8 (19): : 5320 - 5335
  • [5] Bondeson DP, 2015, NAT CHEM BIOL, V11, P611, DOI [10.1038/NCHEMBIO.1858, 10.1038/nchembio.1858]
  • [6] Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome
    Bourdenx, Mathieu
    Martin-Segura, Adrian
    Scrivo, Aurora
    Rodriguez-Navarro, Jose A.
    Kaushik, Susmita
    Tasset, Inmaculada
    Diaz, Antonio
    Storm, Nadia J.
    Xin, Qisheng
    Juste, Yves R.
    Stevenson, Erica
    Luengo, Enrique
    Clement, Cristina C.
    Choi, Se Joon
    Krogan, Nevan J.
    Mosharov, Eugene, V
    Santambrogio, Laura
    Grueninger, Fiona
    Collin, Ludovic
    Swaney, Danielle L.
    Sulzer, David
    Gavathiotis, Evripidis
    Cuervo, Ana Maria
    [J]. CELL, 2021, 184 (10) : 2696 - +
  • [7] Liposomal Formulations in Clinical Use: An Updated Review
    Bulbake, Upendra
    Doppalapudi, Sindhu
    Kommineni, Nagavendra
    Khan, Wahid
    [J]. PHARMACEUTICS, 2017, 9 (02)
  • [8] Bifunctional small molecules that mediate the degradation of extracellular proteins
    Caianiello, David F.
    Zhang, Mengwen
    Ray, Jason D.
    Howell, Rebecca A.
    Swartzel, Jake C.
    Branham, Emily M. J.
    Chirkin, Egor
    Sabbasani, Venkata R.
    Gong, Angela Z.
    McDonald, David M.
    Muthusamy, Viswanathan
    Spiegel, David A.
    [J]. NATURE CHEMICAL BIOLOGY, 2021, 17 (09) : 947 - 953
  • [9] Fundamental aspects of DMPK optimization of targeted protein degraders
    Cantrill, Carina
    Chaturvedi, Prasoon
    Rynn, Caroline
    Schaffland, Jeannine Petrig
    Walter, Isabelle
    Wittwer, Matthias B.
    [J]. DRUG DISCOVERY TODAY, 2020, 25 (06) : 969 - 982
  • [10] p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis
    Cha-Molstad, Hyunjoo
    Yu, Ji Eun
    Feng, Zhiwei
    Lee, Su Hyun
    Kim, Jung Gi
    Yang, Peng
    Han, Bitnara
    Sung, Ki Woon
    Yoo, Young Dong
    Hwang, Joonsung
    McGuire, Terry
    Shim, Sang Mi
    Song, Hyun Dong
    Ganipisetti, Srinivasrao
    Wang, Nuozhou
    Jang, Jun Min
    Lee, Min Jae
    Kim, Seung Jun
    Lee, Kyung Ho
    Hong, Jin Tae
    Ciechanover, Aaron
    Mook-Jung, Inhee
    Kim, Kwang Pyo
    Xie, Xiang-Qun
    Kwon, Yong Tae
    Kim, Bo Yeon
    [J]. NATURE COMMUNICATIONS, 2017, 8
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