Encapsulated iodine-chitosan graphene oxide nanocomposite: fabrication and evaluation for antibacterial activity

被引：1

作者：

Chhabra, Priyanka ^{[1
,6
]}

Chauhan, Gaurav ^{[2
]}

Gupta, Anjali ^{[3
]}

Tripathy, Divya ^{[3
]}

Tyagi, Amit ^{[4
]}

Chauhan, Robin ^{[5
]}

机构：

[1] Amity Univ Noida, Amity Inst Biotechnol, Ctr Med Biotechnol, Noida, India

[2] Tecnol Monterrey, Sch Engn & Sci, Monterrey, Mexico

[3] Galgotias Univ, Sch Basic & Appl Sci, Greater Noida, India

[4] DRDO, Inst Nucl Med & Allied Sci, Div CBRN, Delhi, India

[5] Shivalik Coll Pharm, Pharm, Rupnagar, India

[6] Amity Univ, Amity Inst Biotechnol, Ctr Med Biotechnol, Noida 201301, Uttar Pradesh, India

来源：

POLYMER-PLASTICS TECHNOLOGY AND MATERIALS | 2024年 / 63卷 / 09期

关键词：

Chitosan; graphene oxide; iodine; nanoparticles; wound healing; SILVER NANOPARTICLES; GEL; TOXICITY; EFFICACY; DELIVERY; ACID;

D O I：

10.1080/25740881.2024.2325424

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Chronic wounds pose a significant challenge to wound care professionals and have substantial cause of socioeconomic implications worldwide. This study focuses on the development of a gel containing encapsulated iodine-chitosan graphene oxide nanopockets (I-CH-GO-NPOs) with a comprehensive evaluation to discern its potential in enhancing the wound healing trajectory for full thickness chronic wounds. The prepared I-CH-GO-NPOs gel showed higher antibacterial property of 0.00513 +/- 0.00014 mg/ml against gram-positive Staphylococcus aureus bacteria. Further, in vivo wound healing efficacy of I-CH-GO-NPOs was evaluated in Sprague-Dawley rats which showed a significant increase of 99.89 +/- 2.2% in the wound contraction.

引用

页码：1129 / 1142

页数：14

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