Altered mitochondrial respiration in peripheral blood mononuclear cells of post-acute sequelae of SARS-CoV-2 infection

被引：4

作者：

Dirajlal-Fargo, Sahera ^{[1
,2
]}

Maison, David P. ^{[3
]}

Durieux, Jared C. ^{[1
]}

Andrukhiv, Anastasia ^{[3
]}

Funderburg, Nicholas ^{[4
]}

Ailstock, Kate ^{[4
]}

Gerschenson, Mariana ^{[3
,6
]}

Mccomsey, Grace A. ^{[1
,5
]}

机构：

[1] Case Western Reserve Univ, Cleveland, OH 44106 USA

[2] Ann & Robert H Lurie Childrens Hosp, Chicago, IL USA

[3] Univ Hawaii Manoa, John A Burns Sch Med, Dept Cell & Mol Biol, Honolulu, HI 96822 USA

[4] Ohio State Univ, Sch Hlth & Rehabil Sci, Div Med Lab Sci, Columbus, OH USA

[5] Case Western Reserve Univ, Univ Hosp Cleveland, Pediat & Med, 11100 Euclid Ave,Lakeside 1400F, Cleveland, OH 44106 USA

[6] Univ Hawaii Manoa, John A Burns Sch Med, Cell & Mol Biol, 651 Ilalo St,BSB 211B, Honolulu, HI 96813 USA

来源：

MITOCHONDRION | 2024年 / 75卷

基金：

美国国家卫生研究院;

关键词：

COVID; Long COVID; Mitochondria; PASC; COVID-19; SYMPTOMS;

D O I：

10.1016/j.mito.2024.101849

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Peripheral blood mononuclear cells (PBMC) mitochondrial respiration was measured ex vivo from participants without a history of COVID (n = 19), with a history of COVID and full recovery (n = 20), and with PASC (n = 20). Mean mitochondrial basal respiration, ATP-linked respiration, maximal respiration, spare respiration capacity, ATP-linked respiration, and non-mitochondrial respiration were highest in COVID + PASC+ (p <= 0.04). Every unit increase in non-mitochondrial respiration, ATP-linked respiration, basal respiration, spare respiration capacity, and maximal respiration increased the predicted odds of PASC between 1 % and 6 %. Mitochondrial dysfunction in PBMCs may be contributing to the etiology of PASC.

引用

页数：8

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