Thromboembolic and Bleeding Events in Transthyretin Amyloidosis and Coagulation System Abnormalities: A Review

被引:8
作者
Napolitano, Angela [1 ]
De Michieli, Laura [2 ]
Sinigiani, Giulio [2 ]
Berno, Tamara [3 ]
Cipriani, Alberto [2 ]
Spiezia, Luca [1 ]
机构
[1] Padova Univ Hosp, Dept Med, Gen Internal Med & Thrombot & Haemorrhag Dis Unit, I-35128 Padua, Italy
[2] Padova Univ Hosp, Dept Cardiothorac & Vasc Sci & Publ Hlth, I-35128 Padua, Italy
[3] Padova Univ Hosp, Dept Med, Haematol Unit, I-35128 Padua, Italy
关键词
thromboembolic events; bleeding events; transthyretin amyloidosis; INTRACARDIAC THROMBOSIS; FIBRINOLYTIC SYSTEM; ATRIAL-FIBRILLATION; CARDIAC AMYLOIDOSIS; PREVALENCE; ANGIOPATHY; RHYTHM;
D O I
10.3390/jcm12206640
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Transthyretin amyloidosis (ATTR) is a group of diseases caused by the deposition of insoluble fibrils derived from misfolded transthyretin, which compromises the structure and function of various organs, including the heart. Thromboembolic events and increased bleeding risk are among the most important complications of ATTR, though the underlying mechanisms are not yet fully understood. Transthyretin plays a complex role in the coagulation cascade, contributing to the activation and regulation of the coagulation and fibrinolytic systems. The prevalence of atrial fibrillation, cardiac mechanical dysfunction, and atrial myopathy in patients with ATTR may contribute to thrombosis, though such events may also occur in patients with a normal sinus rhythm and rarely in properly anticoagulated patients. Haemorrhagic events are modest and mainly linked to perivascular amyloid deposits with consequent capillary fragility and coagulation anomalies, such as labile international-normalised ratio during anticoagulant therapy. Therefore, it is paramount to carefully stratify the thrombotic and haemorrhagic risks, especially when initiating anticoagulant therapy. Our review aims to ascertain the prevalence of thromboembolic and haemorrhagic events in ATTR and identify potential risk factors and predictors and their impact on antithrombotic therapy.
引用
收藏
页数:10
相关论文
共 51 条
[1]   Clinical Importance of Left Atrial Infiltration in Cardiac Transthyretin Amyloidosis [J].
Bandera, Francesco ;
Martone, Raffaele ;
Chacko, Liza ;
Ganesananthan, Sharmananthan ;
Gilbertson, Janet A. ;
Ponticos, Markella ;
Lane, Thirusha ;
Martinez-Naharro, Ana ;
Whelan, Carol ;
Quarta, Cristina ;
Rowczenio, Dorota ;
Patel, Rishi ;
Razvi, Yousuf ;
Lachmann, Helen ;
Wechelakar, Ashutosh ;
Brown, James ;
Knight, Daniel ;
Moon, James ;
Petrie, Aviva ;
Cappelli, Francesco ;
Guazzi, Marco ;
Potena, Luciano ;
Rapezzi, Claudio ;
Leone, Ornella ;
Hawkins, Philip N. ;
Gillmore, Julian D. ;
Fontana, Marianna .
JACC-CARDIOVASCULAR IMAGING, 2022, 15 (01) :17-29
[2]   Increased plasmin-α2-antiplasmin levels indicate activation of the fibrinolytic system in systemic amyloidoses [J].
Bouma, B. ;
Maas, C. ;
Hazenberg, B. P. C. ;
Lokhorst, H. M. ;
Gebbink, M. F. B. G. .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2007, 5 (06) :1139-1142
[3]   AMYLOID HEART-DISEASE MANIFESTED BY SYSTEMIC ARTERIAL THROMBOEMBOLI [J].
BROWNE, RS ;
SCHNEIDERMAN, H ;
KAYANI, N ;
RADFORD, MJ ;
HAGER, WD .
CHEST, 1992, 102 (01) :304-306
[4]   Prevalence of Atrial Fibrillation and Thromboembolic Risk in Wild-Type Transthyretin Amyloid Cardiomyopathy [J].
Bukhari, Syed ;
Barakat, Amr F. ;
Eisele, Yvonne S. ;
Nieves, Ricardo ;
Jain, Sandeep ;
Saba, Samir ;
Follansbee, William P. ;
Brownell, Amy ;
Soman, Prem .
CIRCULATION, 2021, 143 (13) :1335-1337
[5]   Cerebral Amyloid Angiopathy With Vascular Iron Accumulation and Calcification A High-Resolution Magnetic Resonance Imaging Histopathology Study [J].
Bulk, Marjolein ;
Moursel, Laure Grand ;
van der Graaf, Linda M. ;
van Veluw, Susanne J. ;
Greenberg, Steven M. ;
van Duinen, Sjoerd G. ;
van Buchem, Mark A. ;
van Rooden, Sanneke ;
van der Weerd, Louise .
STROKE, 2018, 49 (09) :2081-2087
[6]   Arterial thrombo-embolic events in cardiac amyloidosis: a look beyond atrial fibrillation [J].
Cappelli, Francesco ;
Tini, Giacomo ;
Russo, Domitilla ;
Emdin, Michele ;
Del Franco, Annamaria ;
Vergaro, Giuseppe ;
Di Bella, Gianluca ;
Mazzeo, Anna ;
Canepa, Marco ;
Volpe, Massimo ;
Perfetto, Federico ;
Autore, Camillo ;
Di Mario, Carlo ;
Rapezzi, Claudio ;
Musumeci, Maria Beatrice .
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS, 2021, 28 (01) :12-18
[7]   New Oral Anticoagulants vs. Vitamin K Antagonists Among Patients With Cardiac Amyloidosis: Prognostic Impact [J].
Cariou, Eve ;
Sanchis, Kevin ;
Rguez, Khailene ;
Blanchard, Virginie ;
Cazalbou, Stephanie ;
Fournier, Pauline ;
Huart, Antoine ;
Roussel, Murielle ;
Cintas, Pascal ;
Galinier, Michel ;
Carrie, Didier ;
Maury, Philippe ;
Lavie-Badie, Yoan ;
Lairez, Olivier .
FRONTIERS IN CARDIOVASCULAR MEDICINE, 2021, 8
[8]   Atrial Fibrillation in Transthyretin Cardiac Amyloidosis Predictors, Prevalence, and Efficacy of Rhythm Control Strategies [J].
Donnellan, Eoin ;
Wazni, Oussama M. ;
Hanna, Mazen ;
Elshazly, Mohamed B. ;
Puri, Rishi ;
Saliba, Walid ;
Kanj, Mohamed ;
Vakamudi, Sneha ;
Patel, Divyang R. ;
Baranowski, Bryan ;
Cantillon, Daniel ;
Dresing, Thomas ;
Jaber, Wael A. .
JACC-CLINICAL ELECTROPHYSIOLOGY, 2020, 6 (09) :1118-1127
[9]  
DUBREY S, 1995, BRIT HEART J, V74, P541
[10]   Direct Current Cardioversion of Atrial Arrhythmias in Adults With Cardiac Amyloidosis [J].
El-Am, Edward A. ;
Dispenzieri, Angela ;
Melduni, Rowlens M. ;
Ammash, Naser M. ;
White, Roger D. ;
Hodge, David O. ;
Noseworthy, Peter A. ;
Lin, Grace ;
Pislaru, Sorin V. ;
Egbe, Alexander C. ;
Grogan, Martha ;
Nkomo, Vuyisile T. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2019, 73 (05) :589-597