The association between ocular biometric components and corneal aberrations

Clinical relevance Evaluating factors affecting corneal higher-order aberration component has a very important role in interpreting the characteristics of the formed image on the retina.Background To determine the relationship between ocular biometric components and corneal higher-order aberrations in an elderly population.Methods This report is related to a subsample of the Tehran Geriatric Eye study (TGES), a population-based cross-sectional study that was conducted on individuals aged 60 years and above in Tehran city, Iran using multistage stratified random cluster sampling. All study participants underwent ocular examinations including visual acuity measurement, refraction and slit-lamp biomicroscopy. Anterior segment imaging and corneal aberrometry were performed using Pentacam AXL.Results In the present study, 644 eyes of 415 individuals (56.9% female) with mean age of 66.36 +/- 4.70 years were evaluated. According to a multiple generalised estimating equation model, the root mean square of total higher-order aberrations was related to age (beta = 0.081, p = 0.002), crystalline lens thickness (beta = 0.08, p < 0.001), and corneal diameter (beta = -0.04, p = 0.014). The root mean square of total coma aberration was directly related to the female sex (beta = 0.02, p = 0.05), and crystalline lens thickness (beta = 0.06, p < 0.001). There was a direct relationship between the root mean square of third- and fourth-order higher-order aberrations and crystalline lens thickness (p < 0.001). Spherical aberration was directly related to the male sex (beta = -0.02, p = 0.004), axial length (beta = 0.05, p < 0.001) and central corneal thickness (beta = 0.001, p = 0.025), and was inversely related to anterior chamber depth (beta = -0.07, p = 0.031) and crystalline lens thickness (beta = -0.25, p < 0.001).Conclusion Ocular biometric components are related to corneal aberrations in the elderly. These factors need to be considered in respect of medical and surgical procedures required for the elderly.