Role and Therapeutic Targeting Strategies of Neutrophil Extracellular Traps in Inflammation

被引：15

作者：

Li, Xiang ^{[1
]}

Xiao, Shanghua ^{[2
]}

Filipczak, Nina ^{[3
]}

Yalamarty, Satya Siva Kishan ^{[3
]}

Shang, Hongming ^{[4
]}

Zhang, Jing ^{[2
,5
]}

Zheng, Qin ^{[2
,5
]}

机构：

[1] Jiangxi Univ Chinese Med, Natl Pharmaceut Engn Ctr Solid Preparat Chinese He, Nanchang, Jiangxi, Peoples R China

[2] Jiangxi Univ Chinese Med, Key Lab Modern Preparat TCM, Minist Educ, Nanchang, Jiangxi, Peoples R China

[3] Northeastern Univ, Ctr Pharmaceut Biotechnol & Nanomed, Boston, MA USA

[4] Vanderbilt Univ, Dept Biochem & Chem Biol, Nashville, TN USA

[5] Jiangxi Univ Chinese Med, Key Lab Modern Preparat TCM, Minist Educ, Nanchang 330004, Jiangxi, Peoples R China

来源：

INTERNATIONAL JOURNAL OF NANOMEDICINE | 2023年 / 18卷

关键词：

neutrophil extracellular traps; inflammation; targeted inhibition; nanotherapy; herbal medicine; CHROMATIN DECONDENSATION; RHEUMATOID-ARTHRITIS; NLRP3; INFLAMMASOME; NET FORMATION; ELASTASE; NETOSIS; DNA; INHIBITOR; IMMUNITY; AZD9668;

D O I：

10.2147/IJN.S418259

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Neutrophil extracellular traps (NETs) are large DNA reticular structures secreted by neutrophils and decorated with histones and antimicrobial proteins. As a key mechanism for neutrophils to resist microbial invasion, NETs play an important role in the killing of microorganisms (bacteria, fungi, and viruses). Although NETs are mostly known for mediating microbial killing, increasing evidence suggests that excessive NETs induced by stimulation of physical and chemical components, microorganisms, and pathological factors can exacerbate inflammation and organ damage. This review summarizes the induction and role of NETs in inflammation and focuses on the strategies of inhibiting NETosis and the mechanisms involved in pathogen evasion of NETs. Furthermore, herbal medicine inhibitors and nanodelivery strategies improve the efficiency of inhibition of excessive levels of NETs.

引用

收藏

页码：5265 / 5287

页数：23

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