KRASG12C mutation in metastatic colorectal cancer: a new target

被引：1
|
作者：
Ibrahim, Rebecca [1 ]
Saleh, Khalil [1 ]
Chahine, Claude [1 ]
Khoury, Rita [1 ]
Khalife, Nadine [2 ]
Lecesne, Axel [1 ]
机构：
[1] Gustave Roussy Canc Campus, Int Dept, F-94800 Villejuif, France
[2] Gustave Roussy Canc Campus, Dept Head & Neck Oncol, F-94800 Villejuif, France
来源：
FUTURE ONCOLOGY | 2023年 / 19卷 / 24期
关键词：
adagrasib; colorectal cancer; KRAS(G12C) mutation; RAS; sotorasib; INHIBITORS; SOTORASIB;
D O I：
10.2217/fon-2023-0223
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页码：1641 / 1643
页数：3
相关论文
共 50 条
  • [41] Targeting Krasg12c-mutant cancer with a mutation-specific inhibitor
    Christensen, J. G.
    Olson, P.
    Briere, T.
    Wiel, C.
    Bergo, M. O.
    JOURNAL OF INTERNAL MEDICINE, 2020, 288 (02) : 183 - 191
  • [42] A saturation mutagenesis screen uncovers resistant and sensitizing secondary KRAS mutations to clinical KRASG12C inhibitors
    Feng, Siyu
    Callow, Marinella G.
    Fortin, Jean-Philippe
    Khan, Zia
    Bray, David
    Costa, Mike
    Shi, Zhen
    Wang, Weiru
    Evangelista, Marie
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 119 (18)
  • [43] Targeting KRAS G12C Mutation in Colorectal Cancer, A Review: New Arrows in the Quiver
    Ros, Javier
    Vaghi, Caterina
    Baraibar, Iosune
    Saoudi Gonzalez, Nadia
    Rodriguez-Castells, Marta
    Garcia, Ariadna
    Alcaraz, Adriana
    Salva, Francesc
    Tabernero, Josep
    Elez, Elena
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (06)
  • [44] Understanding the influence of AMG 510 on the structure of KRASG12C empowered by molecular dynamics simulation
    Li, Yu
    Han, Lei
    Zhang, Ziding
    COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2022, 20 : 1056 - 1067
  • [45] DNA replication stress and mitotic catastrophe mediate sotorasib addiction in KRASG12C-mutant cancer
    Chiou, Li-Wen
    Chan, Chien-Hui
    Jhuang, Yu-Ling
    Yang, Ching-Yao
    Jeng, Yung-Ming
    JOURNAL OF BIOMEDICAL SCIENCE, 2023, 30 (01)
  • [46] Adagrasib in KRYSTAL-12 has Broken the KRASG12C Enigma Code in Non-Small Cell Lung Carcinoma
    Luo, Faustine X.
    Arter, Zhaohui Liao
    LUNG CANCER-TARGETS AND THERAPY, 2024, 15 : 161 - 167
  • [47] Comparison Between Sotorasib with Docetaxel for the Treatment of Chinese Patients with Previously Treated NSCLC with KRASG12C Mutation: A Cost-Effectiveness Analysis to Inform Drug Pricing
    Yi, Lidan
    Zeng, Xiaohui
    Zhou, Zhen
    Liu, Qiao
    ADVANCES IN THERAPY, 2024, 41 (08) : 3159 - 3172
  • [48] Mercapturate pathway metabolites of sotorasib, a covalent inhibitor of KRASG12C, are associated with renal toxicity in the Sprague Dawley rat
    Werner, Jonathan A.
    Davies, Rhian
    Wahlstrom, Jan
    Dahal, Upendra P.
    Jiang, Min
    Stauber, Jonathan
    David, Benjamin
    Siska, William
    Thomas, Barbara
    Ishida, Katsu
    Humphreys, W. Griffith
    Lipford, J. Russell
    Monticello, Thomas M.
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 2021, 423
  • [49] Non-genetic adaptive resistance to KRASG12C inhibition: EMT is not the only culprit
    Ning, Wenjuan
    Marti, Thomas M. M.
    Dorn, Patrick
    Peng, Ren-Wang
    FRONTIERS IN ONCOLOGY, 2022, 12
  • [50] KRASG12D-Mutated Metastatic Colorectal Cancer: Clinical, Molecular, Immunologic, and Prognostic Features of a New Emerging Targeted Alteration
    Moretto, Roberto
    Rossini, Daniele
    Murgioni, Sabina
    Ciraci, Paolo
    Nasca, Vincenzo
    Germani, Marco Maria
    Calegari, Maria Alessandra
    Vetere, Guglielmo
    Intini, Rossana
    Taravella, Ada
    Studiale, Vittorio
    Boccaccio, Chiara
    Passardi, Alessandro
    Tamburini, Emiliano
    Zaniboni, Alberto
    Salvatore, Lisa
    Pietrantonio, Filippo
    Lonardi, Sara
    Masi, Gianluca
    Cremolini, Chiara
    JCO PRECISION ONCOLOGY, 2024, 8
12345