Mathematical analysis of an age-since infection and diffusion HIV/AIDS model with treatment adherence and Dirichlet boundary condition

In this paper, an epidemic model with homogeneous Dirichlet boundary condition is formulated to study the joint impact of spatial diffusion, infection age and treatment adherence on the HIV/AIDS transmission among humans. It is an interesting problem to understand the threshold dynamics of HIV/AIDS model with the above three factors. Since the complexity of the model and specificity of the boundary condition, there are two main mathematical challenges: i). the compactness of the solution map is not guaranteed; ii). the explicit expression of the basic reproduction cannot be given even if the parameters are spatially independent. We first discuss the well-posedness of the system, then we identify the basic reproduction number R0 as the spectral radius of the next generation operator, followed by the global attractivity of disease-free steady state when R0 < 1, the uniform persistence of the disease and the existence of the endemic steady state when R0 > 1. Numerical simulations are carried out to illustrate our theoretical results, which suggest that the diffusion of individuals has an opposite effect on the disease outbreaks, and improving the treatment compliance of HIV infected individuals can control HIV transmission among the population effectively. & COPY; 2023 International Association for Mathematics and Computers in Simulation (IMACS). Published by Elsevier B.V. All rights reserved.